MABT198
Anti-Connexin-26 Antibody, clone 3B12.1
clone 3B12.1, from mouse
Synonim(y):
Gap junction beta-2 protein, Connexin-26, Cx26
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Wybierz wielkość
100 μG
2060,00 zł
Wybierz wielkość
Zmień widok
100 μG
2060,00 zł
About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
100
200
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
3B12.1, monoclonal
reaktywność gatunkowa
rat, human
metody
immunohistochemistry: suitable
western blot: suitable
izotyp
IgG1κ
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... GJB2(2706)
Opis ogólny
Connexin-2 is also known as Connexin Gap junction beta-2 protein (GJB2) and Connexin-26 (Cx26). The connexins are transmembrane channels that diffuse low MW materials from one cell to a neighboring cell. Aberrant connexin-2 can cause deafness autosomal recessive type 1A (DFNB1A), deafness autosomal dominant type 3A (DFNA3A), Vohwinkel syndrome (VS), palmoplantar keratoderma with deafness (PPKDFN), keratitis-ichthyosis-deafness syndrome (KID syndrome), Bart-Pumphrey syndrome (BPS), and ichthyosis hystrix-like with deafness syndrome (HID syndrome).
Specyficzność
Other homologies: Mouse (92% sequence homology).
Immunogen
KLH-conjugated linear peptide corresponding to human Connexin-26.
Zastosowanie
Anti-Connexin-26 Antibody, clone 3B12.1 is a highly specific mouse monoclonal antibody, that targets CX26 & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: A 1:4,000-8,000 dilution from a representative lot detected Connexin-26 in human colon and human liver tissue.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Adhesion (CAMs)
Adhesion (CAMs)
Jakość
Evaluated by Western Blotting in rat liver tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Connexin-26 in 10 µg of rat liver tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Connexin-26 in 10 µg of rat liver tissue lysate.
Opis wartości docelowych
~26 kDa observed
Postać fizyczna
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Przechowywanie i stabilność
Stable for 1 year at 2-8°C from date of receipt.
Komentarz do analizy
Control
Rat liver tissue lysate
Rat liver tissue lysate
Inne uwagi
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Ming Yang Lee et al.
The Journal of investigative dermatology, 140(5), 1035-1044 (2019-11-11)
Keratitis-ichthyosis-deafness (KID) syndrome is a severe, untreatable condition characterized by ocular, auditory, and cutaneous abnormalities, with major complications of infection and skin cancer. Most cases of KID syndrome (86%) are caused by a heterozygous missense mutation (c.148G>A, p.D50N) in the
Kinga Skieresz-Szewczyk et al.
Cells, 12(13) (2023-07-14)
Connexins are important proteins involved in cell-to-cell communication and cytodifferentiation during renewal and cornification of the multilayered epithelia. So far, there is a lack of reports on this subject in birds' structurally different ortho- and parakeratinized epithelium of the tongue.
Nadine Dilger et al.
Frontiers in cell and developmental biology, 8, 869-869 (2020-09-29)
In vitro transdifferentiation of patient-derived mesenchymal stem/stromal cells (MSCs) into neurons is of special interest for treatment of neurodegenerative diseases. Although there are encouraging studies, little is known about physiological modulations during this transdifferentiation process. Here, we focus on the
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