MAB341
Anti-GABA A Receptor β 2,3 Chain Antibody, clone BD17
clone BD17, Chemicon®, from mouse
Synonim(y):
GABA(A) receptor subunit beta-2, gamma-aminobutyric acid (GABA) A receptor, beta 2, gamma-aminobutyric acid A receptor, beta 2
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Wybierz wielkość
100 μG
3210,00 zł
Wybierz wielkość
Zmień widok
100 μG
3210,00 zł
About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
BD17, monoclonal
reaktywność gatunkowa
mouse, feline, monkey, bovine
reaktywność gatunkowa (przewidywana na podstawie homologii)
rat, human
producent / nazwa handlowa
Chemicon®
metody
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
izotyp
IgG1
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
dry ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... GABRB2(2561)
Opis ogólny
Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels that mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs, including barbiturates, anaesthetics and benzodiazepines.
Specyficzność
Reacts with the β-chain of the GABAA receptor.
Immunogen
Epitope: Extracellular domain of the beta2 & beta3 subunits of the GABAA receptor
Purified GABA/benzodiazepine receptor from bovine cortex
Zastosowanie
Detect GABA A Receptor β 2 using this Anti-GABA A Receptor β 2, 3 Chain Antibody, clone BD17 validated for use in IH, IP & WB.
Immunohistochemistry:
A 10-20 μg/mL concetration of a previous lot was used in IH.
Immunoprecipitation:
A previous lot of this antibody was used in IP.
Western blot:
5-20 µg/mL. Recognizes a 55 kDa band corresponding to the beta chain of the GABAA receptor.
Optimal working dilutions must be determined by end user.
A 10-20 μg/mL concetration of a previous lot was used in IH.
Immunoprecipitation:
A previous lot of this antibody was used in IP.
Western blot:
5-20 µg/mL. Recognizes a 55 kDa band corresponding to the beta chain of the GABAA receptor.
Optimal working dilutions must be determined by end user.
Jakość
Evaluated by Western Blot on mouse brain membrane lysates.
Western Blot:
1:500 dilution of this antibody detected GABA A Receptor β 2,3 Chain on 10 μg of mouse brain membrane lysates.
Western Blot:
1:500 dilution of this antibody detected GABA A Receptor β 2,3 Chain on 10 μg of mouse brain membrane lysates.
Opis wartości docelowych
55 kDa
Powiązanie
Replaces: AB5952
Postać fizyczna
Format: Purified
Purified mouse monoclonal IgG1 liquid in buffer containing 10 mM potassium phosphate buffer pH 7.4 with 150 mM NaCl
Inne uwagi
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informacje prawne
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Human ?1?3?2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state.
Dostalova, Z; Zhou, X; Liu, A; Zhang, X; Zhang, Y; Desai, R; Forman, SA; Miller, KW
Protein Science null
Daniel C Adusei et al.
Neuropharmacology, 59(3), 167-171 (2010-05-18)
Fragile X syndrome is the most common heritable form of mental retardation. It is caused by silencing of the Fmr1 gene and the absence of the encoded protein. The purpose of this study was to examine global protein expression levels
Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells.
Braun, M; Ramracheya, R; Bengtsson, M; Clark, A; Walker, JN; Johnson, PR; Rorsman, P
Diabetes null
Pengju Ma et al.
International journal of clinical and experimental medicine, 8(8), 14296-14302 (2015-11-10)
This study aimed to investigate GABA effects on blood pressure and blood dynamics of anesthetic rats by observing spontaneously hypertensive rats under both anesthesia and waking state. 72 male waking Wistar-Kyokos (WKY) rats and 72 male anesthetized spontaneously hypertensive (SHR)
Mirko Feldmann et al.
Cerebral cortex (New York, N.Y. : 1991), 29(2), 892-905 (2018-12-12)
Although by adulthood cortical structures and their capacity for processing sensory information have become established and stabilized, under conditions of cortical injury, or sensory deprivation, rapid reorganization occurs. Little is known as to the impact of this kind of adaptation
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