ABS2183M

Anti-Coagulation factor VIIa

from rabbit, purified by affinity chromatography

• Synonim(y): Coagulation factor VII, EC: 3.4.21.21, Proconvertin, Serum prothrombin conversion accelerator, SPCA
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• oczyszczone przez: affinity chromatography
• reaktywność gatunkowa: human
• reaktywność gatunkowa (przewidywana na podstawie homologii): primate (based on 100% sequence homology)
• opakowanie: antibody small pack of 25 μg
• metody: immunocytochemistry: suitable; immunofluorescence: suitable; western blot: suitable
• izotyp: IgG
• numer dostępu NCBI: NP_000122
• numer dostępu UniProt: P08709
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... F7(2155)

Opis

Opis ogólny

Coagulation factor VII (UniProt: P08709; also known as EC: 3.4.21.21, Proconvertin, Serum prothrombin conversion accelerator, SPCA) is encoded by the F7 gene (Gene ID: 2155) in human. Coagulation factor VII is a member of the peptidase S1 family that initiates the extrinsic pathway of blood coagulation. It is serine protease that is synthesized with a signal peptide (aa 1-20) and a propeptide (aa 21-60) and circulates in the blood in a zymogen form. The mature form is a heterodimer of a light and a heavy chain. It is a vitamin K-dependent protease that binds to calcium following enzymatic carboxylation of some glutamate residues. Factor VII is converted to Factor VIIa by the action of Factor Xa, Factor XIIa, Factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, Factor VIIa converts factor X to factor Xa by cleavage of Arg-|-Ile bond. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium. Factor VII deficiency resulting from mutations in F7 gene can lead to hemorrhagic complications.

Specyficzność

This rabbit polyclonal antibody detects coagulation factor VIIa in human.

Immunogen

Full-length human recombinant Coagulation factor VIIa.

Zastosowanie

Anti-Coagulation factor VIIa Antibody, Cat. No. ABS2183, is a rabbit polyclonal antibody that detects Coagulation factor VIIa and has been tested for use in Immunocytochemistry, Immunofluorescence, and Western Blotting.

Immunofluorescence Analysis: A representative lot detected Coagulation factor VIIa in endothelial cell cultures incubated with rFVIIa (6 mg/mL) for 2 h at 37˚C.

Immunocytochemistry Analysis: A representative lot detected Coagulation factor VIIa in umbilical cord veins.

Jakość

Evaluated by Western Blotting in human placental tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Coagulation factor VIIa in 10 µg of human placental tissue lysate.

Opis wartości docelowych

~57 kDa observed; 51.59 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

Inne uwagi

Concentration: Please refer to lot specific datasheet.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable