8.14727

Brij^® 58

for synthesis

• Synonim(y): Brij^® 58, Polyoxyethylene (20) cetylether, Polyethyleneglycol (20) cetylether
• Wzór liniowy: HO-(CH₂CH₂O)_n-(CH₂)₁₅-CH₃
• Numer CAS: 9004-95-9
• Numer MDL: MFCD00080892
• Kod UNSPSC: 12352104
• Numer indeksu EC: 500-014-1
• NACRES: NA.22

Właściwości

• Poziom jakości: 200
• Postać: solid
• siła działania: 2500 mg/kg LD₅₀, oral (Rat)
• mp: 38-42 °C
• temp. przejścia: flash point >149 °C
• temp. przechowywania: 2-30°C
• InChI: 1S/C56H114O21/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17-58-19-21-60-23-25-62-27-29-64-31-33-66-35-37-68-39-41-70-43-45-72-47-49-74-51-53-76-55-56-77-54-52-75-50-48-73-46-44-71-42-40-69-38-36-67-34-32-65-30-28-63-26-24-61-22-20-59-18-16-57/h57H,2-56H2,1H3
• Klucz InChI: NLMKTBGFQGKQEV-UHFFFAOYSA-N

Opis

Zastosowanie

• Potential Activity of Micafungin and Amphotericin B Co-Encapsulated in Nanoemulsion against Systemic Candida auris Infection in a Mice Model.: This study investigates the use of Brij® 58 in formulating a nanoemulsion to enhance the efficacy of micafungin and amphotericin B against systemic Candida auris infections in mice. The results suggest significant improvements in drug delivery and antifungal activity (Marena et al., 2024).
• Encapsulation of Pure Water-Stable Perovskite Nanocrystals (PNCs) into Biological Environment-Stable PNCs for Cell Imaging.: This research highlights the role of Brij® 58 in stabilizing perovskite nanocrystals, enhancing their stability and applicability in biological environments for cell imaging purposes (Zheng et al., 2024).
• Improving Drug Delivery on Candida Albicans Using Geraniol Nanoemulsion.: This paper discusses the use of Brij® 58 in geraniol nanoemulsions to enhance drug delivery against Candida albicans, showing improved antifungal effectiveness and stability (Silva Pontes et al., 2023).
• Combined Effect of Shaking Orbit and Vial Orientation on the Agitation-Induced Aggregation of Proteins.: Brij® 58 is utilized in this study to prevent protein aggregation in pharmaceutical formulations during agitation, highlighting its importance in maintaining protein stability (Dasnoy et al., 2024).

Komentarz do analizy

Hydroxyl value: 45 - 60
Water (K. F.): ≤ 3.0 %
Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.

Informacje prawne

Brij is a registered trademark of Croda International PLC

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS09
• Zwroty wskazujące rodzaj zagrożenia: H411
• Zwroty wskazujące środki ostrożności: P273 - P391 - P501
• Klasyfikacja zagrożeń: Aquatic Chronic 2
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): 302.0 °F - closed cup
• Temperatura zapłonu (°C): 150 °C - closed cup