The stability of a 0.001% solution at 4°C has not been tested. A solution of 100 mg/ml in water is stable for 1 year at -80°C and for 1 month at -20°C. It is recommended to aliquot the stock solutions to avoid repeated freeze-thaw cycles.
K4894
Poloxamer 188
solid
Synonim(y):
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol F68
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500 G
892,00 zł
892,00 zł
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Pozwól nam pomócSMILES string
O2C(C2)C.O1CC1
InChI
1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key
RVGRUAULSDPKGF-UHFFFAOYSA-N
agency
USP/NF, meets USP testing specifications
form
solid
mol wt
8.400 g/mol
pH
5.0-7.5(2.5% solution)
application(s)
sample preservation
Quality Level
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Ta pozycja | |||
|---|---|---|---|
| form solid | form solid | form solid, waxy solid | form powder |
| application(s) sample preservation | application(s) liquid formulation | application(s) - | application(s) - |
| Quality Level 300 | Quality Level 500 | Quality Level 100 | Quality Level 100 |
| mol wt 8.400 g/mol | mol wt - | mol wt - | mol wt - |
| agency USP/NF | agency NF, Ph. Eur. | agency - | agency - |
| pH 5.0-7.5(2.5% solution) | pH 5-7.5 (20 °C, 10 g/L in H2O) | pH 5.0-7.5 | pH 5.0-7.5 |
General description
Poloxamer 188 is a non-ionic amphiphilic copolymer, which has a central chain of hydrophobic polyoxypropylene and a hydrophilic polyoxyethylene at the ends.[1]
Application
Poloxamer 188 has been used as a supplement in F17 medium for the culture of HEK293-6E cells. It has also been used as a component of flow cytometry (FACS) buffer as a non-ionic detergent that protects cells from hydrodynamic damage.
Poloxamer 188 has been used as a component of cell-dissociation/minimal essential media (MEM) to sort tumor cells using EpCAM antibody-conjugated magnetic beads.[2]
Biochem/physiol Actions
Poloxamer 188 exhibits cytoprotective, hemorheological, anti-inflammatory, antithrombotic activities. It maintains the stability of membrane barrier function. P188 lowers surface tension and hydrophobic-based cellular adherence. It also inhibits lipid peroxidation stimulated by Fe2+ and H2O2.[1]
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Klasa składowania
11 - Combustible Solids
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Unlike other malignancies, therapeutic options in pancreatic ductal adenocarcinoma (PDAC) are largely limited to cytotoxic chemotherapy without the benefit of molecular markers predicting response. Here we report tumor-cell-intrinsic chromatin accessibility patterns of treatment-naïve surgically resected PDAC tumors that were subsequently
S Dhara et al.
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Martin Emanuele et al.
Drugs in R&D, 14(2), 73-83 (2014-04-12)
Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer with hemorheologic, antithrombotic, anti-inflammatory, and cytoprotective properties. It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb ischemia, shock, acute stroke, heart failure, and sickle cell crisis.
Gustavo H Rodrigues da Silva et al.
Scientific reports, 10(1), 19733-19733 (2020-11-14)
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How long can a 0,001% solution be stored at 4°C?
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