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Merck

15759

Poloxamer 188

Synonim(y):

Lutrol F68

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1 KG

556,00 zł

556,00 zł

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Informacje o tej pozycji

Numer CAS:
9003-11-6
UNSPSC Code:
12352104
NACRES:
NA.25
MDL number:
MFCD00082049

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SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

form

solid

mol wt

~7680-9510 g/mol

composition

oxyethylene, 79.9-83.7%

impurities

≤0.25% ethylene glycol and diethylene glycol, ≤0.4% total ash, ≤1 ppm ethylene oxide, ≤1.0% water, ≤2 ppm arsenic traces, ≤20 ppm heavy metals, ≤5 ppm dioxan, ≤5 ppm propylene oxide, 50-150 ppm butylhydroxytoluene

ign. residue

≤0.30%

color

APHA: ≤120, 50/50 in CH3OH

pH

5.0-7.5 (100 g/L in H2O), 6.0-7.5 (25 g/L in H2O)

CMC

0.48 mM

transition temp

cloud point >100 °C

HLB

>24

Quality Level

200

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Ta pozycja
1.37112P2163920P2164020
Poloxamer 188

Sigma-Aldrich

15759

Poloxamer 188

Poloxamer 188 EMPROVE® EXPERT, (stabilized with 70ppm BHT), Ph. Eur., ChP, NF

SAFC

1.37112

Poloxamer 188

Poloxamer 124 European Pharmacopoeia (EP) Reference Standard

P2163920

Poloxamer 124

Poloxamer 237 European Pharmacopoeia (EP) Reference Standard

P2164020

Poloxamer 237

form

solid

form

solid

form

-

form

-

HLB

>24

HLB

-

HLB

-

HLB

-

impurities

≤0.25% ethylene glycol and diethylene glycol, ≤1 ppm ethylene oxide, ≤2 ppm arsenic traces, ≤5 ppm dioxan, 50-150 ppm butylhydroxytoluene, ≤0.4% total ash, ≤20 ppm heavy metals, ≤1.0% water, ≤5 ppm propylene oxide

impurities

-

impurities

-

impurities

-

CMC

0.48 mM

CMC

-

CMC

-

CMC

-

mol wt

~7680-9510 g/mol

mol wt

-

mol wt

-

mol wt

-

Quality Level

200

Quality Level

500

Quality Level

-

Quality Level

-

Application


  • Stabilizująca funkcja P 188 w preparatach dermalnych: Zbadany pod kątem jego stabilizującego wpływu na przemysłowe koncentraty dermalnych hesperydyn smartCrystals, P 188 przyczynił się do zwiększenia długoterminowej stabilności preparatów, istotnych dla dermalnych interwencji terapeutycznych (Romero et al., 2015).

Biochem/physiol Actions

Poloxamer 188 is widely used as a thickening agent and gel binder.

Other Notes

The Poloxamer 188 grades are poloxamers from the extensive line of block copolymers.

Legal Information

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Klasa składowania

11 - Combustible Solids

wgk

WGK 1

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
BCCN6034
BCCN6032
BCCN0958
BCCL8783
BCCM5491

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Céline Durand-Gasselin et al.
Langmuir : the ACS journal of surfaces and colloids, 27(20), 12329-12335 (2011-09-29)
Aggregation of thermosensitive polymer-coated gold nanoparticles was performed in aqueous solution in the presence of a triblock copolymer poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic P123, PEO(20)-PPO(68)-PEO(20)). The gold nanoparticles, AuNPs, which are covered by thermosensitive statistical copolymers poly(EO(x)-st-PO(y)), aggregate when the
Jianan Shen et al.
Biomaterials, 34(5), 1581-1590 (2012-11-14)
The metastasis of breast cancer is the leading cause of cancer death in women, and the lung is a common location of a secondary tumor that has metastasized from the primary source tumor. In this work, an attempt to simultaneously
Irshad A Wani et al.
Colloids and surfaces. B, Biointerfaces, 101, 243-250 (2012-09-27)
Silver nanoparticles have been synthesized in the inverse microemulsions formed using three different surfactants viz., cetyl-trimethyl ammonium bromide (CTAB), Tergitol and Triton X-100. We have done a systematic study of the effect of the surfactants on the particle size and
Wendell J Lu et al.
Lipids, 47(6), 571-580 (2012-02-03)
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins produced in the intestine that play a central role in glucose metabolism and insulin secretion. Circulating concentrations of GLP-1 and GIP are low and can be difficult to assay in
Tsz Chung Lai et al.
Colloids and surfaces. B, Biointerfaces, 99, 27-37 (2011-10-18)
Polyplex particles formed with plasmid DNA (pDNA) and Pluronic P85-block-poly{N-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} (P85-b-P[Asp(DET)]) demonstrated highly effective transfection ability compared to PEG-based block cationomer, PEG-b-P[Asp(DET)]. Ternary polyplexes comprising PEG-b-P[Asp(DET)], poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-b-P[Asp(DET)] (P(EPE)-b-P[Asp(DET)]) used as an analog of P85-b-P[Asp(DET)], and pDNA were
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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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