553590

Ratjadone A

InSolution, ≥95%, Synthetic

• Synonim(y): InSolution Ratjadone A, Synthetic, Ratjadon, Chromosome Region Maintenance 1 Protein Inhibitor II, CRM1 Inhibitor II, Exportin 1 Inhibitor II, XPO1 Inhibitor II
• Wzór empiryczny (zapis Hilla): C₂₈H₄₀O₅
• Numer CAS: 163564-92-9
• Masa cząsteczkowa: 456.61
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥95% (HPLC)
• Postać: liquid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• rozpuszczalność: aqueous buffer: ≤100 μM; methanol: 20 mg/mL
• Warunki transportu: wet ice
• temp. przechowywania: −70°C
• InChI: 1S/C28H40O5/c1-6-9-26-22(5)25(30)18-27(33-26)24(29)12-7-10-19(2)16-21(4)17-20(3)14-15-23-11-8-13-28(31)32-23/h6-10,12-15,17,21-27,29-30H,11,16,18H2,1-5H3/b9-6+,12-7+,15-14+,19-10+,20-17-/t21-,22+,23-,24-,25-,26+,27+/m1/s1
• Klucz InChI: CAYGMWMWJUFODP-AYFTZVAISA-N

Opis

Opis ogólny

A cell-permeable polyketide that displays potent anti-tumor properties in eukaryotes. Originally identified as a metabolite from the myxobacterium Sorangium cellulosum for its antibiotic activities against yeast and filamentous fungi. Ratjadones act by inhibiting nuclear export of LR-NES (leucine rich-nuclear export signal)-containing proteins by covalently binding to CRM1. Inhibits proliferation (IC₅₀ ≤1 ng/ml) and induces cell cycle arrest at the G1 phase.

A cell-permeable polyketide that displays potent antitumor properties in eukaryotes. Originally identified as a metabolite from the myxobacterium Sorangium cellulosum for its antibiotic activities against yeasts and filamentous fungi, ratjadones inhibit nuclear export of LR-NES (leucine rich-nuclear export signal)-containing proteins by covalently binding to CRM1. Inhibits proliferation (IC₅₀ ≤ 1 ng/ml) and induces cell cycle arrest at G1 phase.

Działania biochem./fizjol.

Cell permeable: yes

Primary Target
nuclear export of LR-NES

Product does not compete with ATP.

Reversible: no

Target IC₅₀: ≤ 1 ng/ml for inhibiting proliferation and inducing cell cycle arrest at G1 phase

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Flammable (J)

Postać fizyczna

A 5 µg/ml solution (2 µg in 400 µl) in methanol.

Rekonstytucja

Following initial thaw, aliquot and freeze (-70°C).

Inne uwagi

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Köster, M., et al. 2003. Exp. Cell Res.286, 321.
Kalesse, M., et al. 2001. Chem biochem2, 709.
Gerth, K., et al. 1995. J. Antibiot.48, 973.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02,GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H225,H301 + H311 + H331,H370
• Zwroty wskazujące środki ostrożności: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Klasyfikacja zagrożeń: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organy docelowe: Eyes,Central nervous system
• Kod klasy składowania: 3 - Flammable liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): 49.5 °F
• Temperatura zapłonu (°C): 9.7 °C