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344827

Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose

2F-Peracetyl-Fucose is a cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic.

Synonim(y):

Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose, (3S,4R,5R,6S)-3-fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triyl triacetate

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Gabaryty przesyłkiSKUDostępnośćCena netto
10 mg

Dostępny do wysyłki w dniu14 maja 2026zKuehne + Nagel Sp. z o.o.

1400,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C12H17FO7
Masa cząsteczkowa:
292.26
NACRES:
NA.77
UNSPSC Code:
12352111
Assay:
≥98% (NMR)
Form:
solid
Quality level:
300
Storage condition:
OK to freeze, protect from light

1400,00 zł

Dostępny do wysyłki w dniu14 maja 2026Szczegóły

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Quality Level

300

assay

≥98% (NMR)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic. Treatment of HL-60 cells with this inhibitor shows complete abolition of Lewis-X and SLex within 3 days. Also abolishes P-selectin binding and exhibits faster rolling cells on E-selectin and P-selectin coated surfaces. Does not affect cell viability or their doubling time even at 200 µM levels.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Fucosyltransferase
Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Rillahan, C., et al. 2012.. Nat. Chem. Bio.8, 661.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)
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Ta pozycja
566224344355124009
Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose 2F-Peracetyl-Fucose is a cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic.

Sigma-Aldrich

344827

Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose

Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac The Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac controls the biological activity of Sialyltransferase.

Sigma-Aldrich

566224

Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac

Foxo1 Inhibitor, AS1842856 Foxo1 Inhibitor, AS1842856, is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 (IC50 = 33 nM). Directly binds to the active Foxo1, but not the Ser256-phosphorylated form.

Sigma-Aldrich

344355

Foxo1 Inhibitor, AS1842856

Akt Inhibitor III The Akt Inhibitor III controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

124009

Akt Inhibitor III

assay

≥98% (NMR)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (NMR)

form

solid

form

solid

form

solid

form

solid

Quality Level

300

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−70°C

storage temp.

2-8°C

storage temp.

−20°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze

Klasa składowania

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

Martina Zimmermann et al.
Biotechnology and bioengineering, 118(5), 1818-1831 (2021-01-28)
The reduction of antibody core-fucosylation is known to enhance antibody-dependent cellular cytotoxicity (ADCC). In this study, 5-Thio-l-Fucose (ThioFuc) was investigated as a media and feed supplement for modulating the fucosylation profile of therapeutic proteins and, thereby, improving the resulting effector
Natalie K Thulin et al.
Cell reports, 31(6), 107642-107642 (2020-05-14)
Infant mortality from dengue disease is a devastating global health burden that could be minimized with the ability to identify susceptibility for severe disease prior to infection. Although most primary infant dengue infections are asymptomatic, maternally derived anti-dengue immunoglobulin G
Sotiria Pinioti et al.
Cancer immunology research, 11(12), 1611-1629 (2023-11-07)
Forkhead box P3 (Foxp3)-expressing regulatory T cells (Treg) are the guardians of controlled immune reactions and prevent the development of autoimmune diseases. However, in the tumor context, their increased number suppresses antitumor immune responses, indicating the importance of understanding the
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SKUNUMER GTIN
344827-10MG04055977214833

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