This product is a 100 mM (10 mg/438 µl) solution of 5-Aza-2'-Deoxycytidine in DMSO. Mixing with additional DMSO is not necessary.
189826
5-Aza-2′-Deoksycytydyna
≥98% (HPLC), liquid, DNA methyltransferase inhibitor, Calbiochem
Synonim(y):
Decytabina, InSolution 5-Aza-2′-Deoksycytydyna
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 10 mg | Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o. | 763,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C8H12N4O4
Numer CAS:
Masa cząsteczkowa:
228.21
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
763,00 zł
Dostępne do wysyłki DZISIAJSzczegóły
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
5-Aza-2′-Deoksycytydyna, InSolution, ≥98%, DNA methyltransferase inhibitor
Quality Segment
assay
≥98% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
ambient
storage temp.
−20°C
SMILES string
N2(C=NC(=N)NC2=O)C1OC(C(C1)O)CO
InChI
1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)
InChI key
XAUDJQYHKZQPEU-UHFFFAOYSA-N
General description
A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available.
Packaging
Packaged under inert gas
Physical form
A 100 mM (10 mg/438 µl) solution of 5-Aza-2ʹ-Deoxycytidine (Cat. No. 189825) in DMSO.
Other Notes
Eggert, A., et al. 2001. Cancer Res.61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Regulatory Review (Z)
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Ta pozycja | |||
|---|---|---|---|
| form liquid | form lyophilized | form solid | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥97% |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename - |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. - |
| storage condition OK to freeze, protect from light, desiccated (hygroscopic) | storage condition OK to freeze | storage condition OK to freeze | storage condition - |
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signalword
Danger
hcodes
Hazard Classifications
Muta. 2 - Repr. 1B
Klasa składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
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Cancer is a complex disease manifestation. At its core, it remains a disease of abnormal cellular proliferation and inappropriate gene expression. In the early days, carcinogenesis was viewed simply as resulting from a collection of genetic mutations that altered the gene expression of key oncogenic genes or tumor suppressor genes leading to uncontrolled growth and disease (Virani, S et al 2012). Today, however, research is showing that carcinogenesis results from the successive accumulation of heritable genetic and epigenetic changes. Moreover, the success in how we predict, treat and overcome cancer will likely involve not only understanding the consequences of direct genetic changes that can cause cancer, but also how the epigenetic and environmental changes cause cancer (Johnson C et al 2015; Waldmann T et al 2013). Epigenetics is the study of heritable gene expression as it relates to changes in DNA structure that are not tied to changes in DNA sequence but, instead, are tied to how the nucleic acid material is read or processed via the myriad of protein-protein, protein-nucleic acid, and nucleic acid-nucleic acid interactions that ultimately manifest themselves into a specific expression phenotype (Ngai SC et al 2012, Johnson C et al 2015). This review will discuss some of the principal aspects of epigenetic research and how they relate to our current understanding of carcinogenesis. Because epigenetics affects phenotype and changes in epigenetics are thought to be key to environmental adaptability and thus may in fact be reversed or manipulated, understanding the integration of experimental and epidemiologic science surrounding cancer and its many manifestations should lead to more effective cancer prognostics as well as treatments (Virani S et al 2012).
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| 189826-10MG | 04055977222050 |
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