189404

Aurora Kinase Inhibitor II

The Aurora Kinase Inhibitor II, also referenced under CAS 331770-21-9, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonim(y): Aurora Kinase Inhibitor II, 4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline, Aurora Kinase Inhibitor II
• Wzór empiryczny (zapis Hilla): C₂₃H₂₀N₄O₃
• Numer CAS: 331770-21-9
• Masa cząsteczkowa: 400.43
• Kod UNSPSC: 12352200

Właściwości

• Poziom jakości: 100
• Próba: ≥90% (HPLC)
• Postać: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• kolor: yellow
• rozpuszczalność: DMSO: 5 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: 2-8°C
• InChI: 1S/C23H20N4O3/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)26-16-8-10-17(11-9-16)27-23(28)15-6-4-3-5-7-15/h3-14H,1-2H3,(H,27,28)(H,24,25,26)
• Klucz InChI: IMYVCWQAHSYYOO-UHFFFAOYSA-N

Opis

Opis ogólny

A cell-permeable anilinoquinazoline compound that acts as a potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC₅₀ = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.

A cell-permeable, potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC₅₀ = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.

Działania biochem./fizjol.

Cell permeable: yes

Primary Target
Aurora Kinase

Product competes with ATP.

Reversible: no

Target IC₅₀: 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Standard Handling (A)

Inne uwagi

Heron, N.M., et al. 2006. Bioorg. Med. Chem. Lett.16, 1320.
Mortlock, A.A., et al. 2005. Curr. Top. Med. Chem.5, 807.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable