860058P

Ganglioside GM3 (Bovine Milk)

Avanti Research^™ - A Croda Brand

• Synonim(y): 110953
• Numer CAS: 1246353-19-4
• Kod UNSPSC: 12352211
• NACRES: NA.25

Właściwości

• opis: GM3 Ganglioside (Milk, Bovine-Ammonium Salt)
• Próba: >99% (TLC)
• Formularz: powder
• opakowanie: pkg of 1 × 1 mg (860058P-1mg); pkg of 1 × 10 mg (860058P-10mg); pkg of 1 × 25 mg (860058P-25mg); pkg of 1 × 5 mg (860058P-5mg)
• producent / nazwa handlowa: Avanti Research^™ - A Croda Brand
• typ lipidu: sphingolipids
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• ciąg SMILES: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H]([C@H](O[C@@]3(C([O-])=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@@](NC(C)=O)([H])[C@@H](O)C3)[C@H]2O)O)[C@@H](CO)O1.[NH4+]
• InChI: 1S/C59H108N2O21.H3N/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-46(69)61-40(41(66)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)38-77-56-51(73)50(72)53(45(37-64)79-56)80-57-52(74)55(49(71)44(36-63)78-57)82-59(58(75)76)34-42(67)47(60-39(3)65)54(81-59)48(70)
• Klucz InChI: WFQOHDPRXSLGNK-BLVJLEROSA-N

Opis

Opis ogólny

Ganglioside monosialodihexosylganglioside (GM3) are glycosphingolipids (GSLs), which are membrane-bound consisting of a sialic acid residue and an oligosaccharide head structure.[1] It is found in milk and kidney cells.[2] GM3 is the most broadly distributed ganglioside in tissues.[1]

Zastosowanie

Ganglioside GM3 (Bovine Milk) has been used in lipid binding assay to assess the binding of monoclonal antibodies (mAbs).[3] It may be used as a standard to investigate the efficiency of ganglioside extraction in brain using electrospray ionization-mass spectrometry (ESI MS) analysis.[4] It may also be used for the structural characterization of gangliosides using ultraviolet photodissociation mass spectrometry.[5]

Działania biochem./fizjol.

Ganglioside monosialodihexosylganglioside (GM3) blocks the activity of fibroblast growth factor receptor. GM3-enriched microdomain is involved in modulating cell growth. Low levels of ganglioside GM3 is involved in the pathogenesis of rheumatoid arthritis.[1] GM3 regulates immunological functions by preventing cytokine production.[1] It regulates apoptosis, cell proliferation and differentiation. GM3 is also involved in cellular signaling pathways, cell adhesion and mobility. Increased GM3 levels are associated with diabetic nephropathy.[6]

Opakowanie

5 mL Amber Glass Screw Cap Vial (860058P-10mg)

5 mL Amber Glass Screw Cap Vial (860058P-1mg)

5 mL Amber Glass Screw Cap Vial (860058P-25mg)

5 mL Amber Glass Screw Cap Vial (860058P-5mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids