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911860

Sigma-Aldrich

NanoFabTx™ microfluidic - micro

device kit for synthesis of 1-5 μm particles

Synonim(y):

Microfluidic kit, Microparticle, NanoFabTx™ device kit, Nanoformulation

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Wszystkie zdjęcia(3)

About This Item

Kod UNSPSC:
12162002
Kod UNSPSC:
41121811
NACRES:
NA.23

opis

Microfludic device kit for synthesizing 1-5 μm microparticles

Kit components :

  • Microfluidic chip x 1
  • Tubings and accessories

Poziom jakości

100

Zastosowanie

advanced drug delivery

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Opis ogólny

NanoFabTx™ Microfluidic - micro device kit includes a comprehensive protocol, pre-assembled microfluidic chip manifold, tubing, and accessories—a microfluidic platform to synthesize drug-encapsulating microparticles 1-5 μm in size. It is compatible with either a standard syringe pump (not included) or the Dolomite microfluidics system (not included). The device kit does not include reagents. NanoFabTx™- micro reagent kits, like NanoFabTx™ PLGA-micro (Cat.No. 912220) provide the reagents for the synthesis of 1-5 μm PLGA microparticles.

Zastosowanie

NanoFabTx™ Microfluidic - micro device kit is designed to work with the NanoFabTx™- micro reagent kits for the synthesis of 1-5 μm particles (Cat.No. 912220) and can be used to create drug-encapsulated polymeric microspheres with narrow size-dispersity and consistent drug loading. Polymeric microparticles also can encapsulate larger biologics like proteins, mRNA, and DNA, in addition to drugs and small molecules, and may serve as vehicles for targeted delivery and controlled release. Microfluidic-based synthesis is a powerful tool in drug development for fabricating size-controlled drug-delivery particles, enabling scalable synthesis of particles and rapid formulation screening. In contrast to nanoprecipitation or solvent-displacement methods, microfluidic technologies have several advantages including enhanced reproducibility, less consumption of expensive reagents, and superior scalability.

Cechy i korzyści

  • Step-by-step microfluidic-based protocols developed and tested by our formulation scientists
  • Optimized to make monodisperse microparticles of any size between 1 and 5 μm
  • Facilitates simple optimization of drug encapsulation and loading efficiency in microparticles

Informacje prawne

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

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Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Andrew Gdowski et al.
Journal of nanobiotechnology, 16(1), 12-12 (2018-02-13)
The process of optimization and fabrication of nanoparticle synthesis for preclinical studies can be challenging and time consuming. Traditional small scale laboratory synthesis techniques suffer from batch to batch variability. Additionally, the parameters used in the original formulation must be
Samar Damiati et al.
Genes, 9(2) (2018-02-22)
Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow
Xuanyu Li et al.
Advanced drug delivery reviews, 128, 101-114 (2017-12-27)
Microfluidic chips allow the rapid production of a library of nanoparticles (NPs) with distinct properties by changing the precursors and the flow rates, significantly decreasing the time for screening optimal formulation as carriers for drug delivery compared to conventional methods.

Produkty

NanoFabTx™ Drug Delivery Formulations

NanoFabTx™ platform accelerates drug development with ready-to-use formulations and microfluidic devices for particle synthesis.

NanoFabTx™ Nanoparticle Formulation

NanoFabTX kits enable precise drug delivery with lipid nanoparticles and liposomes for mRNA and nucleic acids.

Flash NanoPrecipitation (FNP) – Principles and Applications in Medical Imaging and Drug Delivery

Professor Robert K. Prud’homme introduces flash nanoprecipitation (FNP) for nanoparticle fabrication, which is a scalable, rapid mixing process for nanoparticle formulations.

Flash NanoPrecipitation (FNP) - zasady i zastosowania w obrazowaniu medycznym i dostarczaniu leków

Profesor Robert K. Prud'homme przedstawia nanoprecypitację błyskawiczną (FNP) do wytwarzania nanocząstek, która jest skalowalnym, szybkim procesem mieszania preparatów nanocząstek.

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