Unless otherwise stated this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption or application to humans or animals. For research purposes, in animal models or in vitro assays, the prepared solution would require filter sterilization.
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Kluczowe dokumenty
347795
Sodium dichloroacetate
98%
Synonim(y):
Dichloroacetic acid sodium salt
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10 G
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452,00 zł
50 G
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About This Item
Wzór liniowy:
Cl2CHCO2Na
Numer CAS:
Masa cząsteczkowa:
150.92
Numer WE:
Numer MDL:
Kod UNSPSC:
12352302
Identyfikator substancji w PubChem:
NACRES:
NA.22
Próba:
98%
452,00 zł
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Polecane produkty
Poziom jakości
Próba
98%
zanieczyszczenia
<2% ethyl alcohol
mp
198 °C (dec.) (lit.)
grupa funkcyjna
chloro
ciąg SMILES
[Na+].[O-]C(=O)C(Cl)Cl
InChI
1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1
Klucz InChI
LUPNKHXLFSSUGS-UHFFFAOYSA-M
informacje o genach
human ... PDK1(5163) , PDK2(5164) , PDK3(5165) , PDK4(5166)
Opis ogólny
Zastosowanie
Sodium dichloroacetate can be used as an organic salt precursor for synthesizing microporous carbon that is useful in developing carbon-based adsorbents.[4]
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Hasło ostrzegawcze
Warning
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organy docelowe
Respiratory system
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
dust mask type N95 (US), Eyeshields, Gloves
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Klienci oglądali również te produkty
Yongchong Yang et al.
European journal of medicinal chemistry, 45(9), 4300-4306 (2010-07-29)
A current study shows that sodium dichloroacetate (DCA) can induce cancer cell apoptosis and inhibit tumor growth, but its cytotoxic activity is low (IC(50) > 1000 microM for A549). In this paper, a variety of DCA derivatives were synthesized, and
Case report: sodium dichloroacetate (DCA) inhibition of the ?Warburg Effect? in a human cancer patient: complete response in non-Hodgkin?s lymphoma after disease progression with rituximab-CHOP.
Strum SB., et al.
Journal of Bioenergetics and Biomembranes, 45(3), 307-315 (2013)
Frank Comhaire
Medical hypotheses, 120, 65-67 (2018-09-18)
Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) is an enigmatic disease the pathogenesis of which remains elusive. Pragmatic proof-of-principle of the hypothetical mechanisms causing the clinical symptoms has been delivered, but it is hard to explain why some patients do respond favourably
Peng Wang et al.
Shock (Augusta, Ga.), 49(6), 704-711 (2017-08-29)
No pharmacological interventions are currently available to provide neuroprotection for patients suffering from cardiac arrest. Dichloroacetate (DCA) is a pyruvate dehydrogenase kinase inhibitor, which activates pyruvate dehydrogenase (PDH), and increases cell adenosine triphosphate (ATP) production by promoting influx of pyruvate
Roald A Lambrechts et al.
EMBO molecular medicine, 11(12), e10488-e10488 (2019-11-09)
PKAN, CoPAN, MePAN, and PDH-E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defects in CoA biosynthesis (PKAN, CoPAN), protein lipoylation
Produkty
Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.
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Is the product sterile and readily soluble in other solution for intravenous use in medical research?
1 answer-
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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I have heard that dichloroacetate has been used for cancer treatment. Is Product 347795, Sodium dichloroacetate, the same chemical?
1 answer-
Some research studies on the use of dichloroacetate as an anti-cancer agent have been performed. At this time, no dichloroacetate compound or product has been approved for use as an anti-cancer drug. The common salts of dichloroacetate are sodium and potassium, and these are what have been used in the research studies. The Sigma-Aldrich products 347795, Sodium Dichloroacetate, and 348082, Potassium Dichloroacetate, are offered for laboratory use only, and are not manufactured or intended for human use.
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How can I make a solution of Product 347795, Sodium dichloroacetate?
1 answer-
Sodium dichloroacetate is soluble in water at 50 mg/ml.
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