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KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

Synonimy:
DFNA2, DFNA2A, KV7.4
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(9132) Summary: The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(60613) potassium voltage-gated channel, subfamily Q, member 4
  • Rat(298496) potassium voltage-gated channel, KQT-like subfamily, member 4
  • chicken(419643) potassium voltage-gated channel, KQT-like subfamily, member 4
  • naked mole-rat(101714294) potassium voltage-gated channel, KQT-like subfamily, member 4
  • domestic guinea pig(100716024) potassium voltage-gated channel, KQT-like subfamily, member 4
  • sheep(101122655) potassium voltage-gated channel, KQT-like subfamily, member 4
  • Domestic Rabbit(100358271) potassium voltage-gated channel, KQT-like subfamily, member 4
  • domestic cat(101091641) potassium voltage-gated channel, KQT-like subfamily, member 4
  • Horse(100067963) potassium voltage-gated channel, KQT-like subfamily, member 4
  • cow(528741) potassium voltage-gated channel, KQT-like subfamily, member 4
  • dog(482451) potassium voltage-gated channel, KQT-like subfamily, member 4

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Small Molecule - Activator

Numer produktu
Opis
Gatunek
BMS 204352, ≥98% (HPLC),
Gatunek
human

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-KCNQ4 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
western blot
Monoclonal Anti-KCNQ4 antibody produced in mouse, clone 2H6, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
mouse
Zastosowanie
ELISA
western blot

Small Molecule - Blocker

Numer produktu
Opis
Gatunek
Retigabine, analytical standard,
Gatunek
human
Retigabine, ≥98% (HPLC),
Gatunek
human
Guanidine hydrochloride solution, BioUltra, ~8 M in H2O,
Gatunek
human
Guanidine hydrochloride solution, Colorless liquid, 7.8 - 8.3 M, pH- 4.5 - 5.5,
Gatunek
human
3,4-Diaminopyridine, ≥98%,
Gatunek
human

Small Molecule - Inhibitor

Numer produktu
Opis
Gatunek
N-Ethylmaleimide, crystalline, ≥98% (HPLC),
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting mouse Kcnq4,
Gatunek
mouse
MISSION® esiRNA, targeting human KCNQ4,
Gatunek
human