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SML0652

IOX2

Name: IOX2
Brand: SIGMA

≥98% (HPLC)

Synonym(e):

JICL38, N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine, N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine

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About This Item

Empirische Formel (Hill-System):

C₁₉H₁₆N₂O₅

CAS-Nummer:

931398-72-0

Molekulargewicht:

352.34

MDL-Nummer:

MFCD22580424

UNSPSC-Code:

12352200

PubChem Substanz-ID:

329825575

NACRES:

NA.77

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Sigma-Aldrich

736147

L-Ornithine-¹³C₅ hydrochloride

Sigma-Aldrich

400083

HIF-1 Inhibitor

Sigma-Aldrich

400084

HIF Prolyl Hydroxylase Inhibitor

Sigma-Aldrich

SCP0004

γ Secretase Inhibitor

Sigma-Aldrich

565789

γγ-Sekretase-Inhibitor XX

Avanti

861809O

oleic acid-d9

Sigma-Aldrich

SML1046

CHIR99021

Sigma-Aldrich

A0231

AS 604850

Sigma-Aldrich

400091

HIF-Hydroxylase-Inhibitor, DMOG

Sigma-Aldrich

C8661

Cobalt(II)-Chlorid Hexahydrat

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: 5 mg/mL, clear (warmed)

Lagertemp.

2-8°C

SMILES String

OC(C1=C(N2CC3=CC=CC=C3)C=CC=C1)=C(C(NCC(O)=O)=O)C2=O

InChI

1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)

InChIKey

CAOSCCRYLYQBES-UHFFFAOYSA-N

Anwendung

IOX2 has been used as PHD inhibitor to induce pseudo-hypoxia.

Biochem./physiol. Wirkung

IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R through inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases (PHD) that exhibits up-regulation of HIF1a in zebrafish. For full characterization details, please visit the IOX2 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Leistungsmerkmale und Vorteile

IOX2 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Signalwort

Danger

H-Sätze

H301

P-Sätze

P264 - P270 - P301 + P310 - P405 - P501

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Sigma-Aldrich

C8661

Cobalt(II)-Chlorid Hexahydrat

Sigma-Aldrich

D9533

Deferoxamin -mesylat (Salz)

Resveratrol integrates metabolic and growth effects in PC3 prostate cancer cells-involvement of prolyl hydroxylase and hypoxia inducible factor-1

Fonseca J, et al.

Oncology Letters (2018)

Inhibition of the Oxygen Sensor PHD2 Enhances Tissue-Engineered Endochondral Bone Formation.

Pieter-Jan Stiers et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 34(2), 333-348 (2018-11-20)

Tissue engineering holds great promise for bone regenerative medicine, but clinical translation remains challenging. An important factor is the low cell survival after implantation, primarily caused by the lack of functional vasculature at the bone defect. Interestingly, bone development and

EZH2 regulates PD-L1 expression via HIF-1α in non-small cell lung cancer cells.

Yuetao Zhao et al.

Biochemical and biophysical research communications, 517(2), 201-209 (2019-07-25)

Lung cancer is the most commonly diagnosed cancer and accounts for most cancer-related mortalities worldwide. The high expression of programmed death ligand 1 (PD-L1) is an important factor that promotes immune escape of lung cancer, thus aggravates chemotherapy resistance and

Acidosis induces antimicrobial peptide expression and resistance to uropathogenic E. coli infection in kidney collecting duct cells via HIF-1α.

Hu Peng et al.

American journal of physiology. Renal physiology, 318(2), F468-F474 (2019-12-17)

Acute pyelonephritis is frequently associated with metabolic acidosis. We previously reported that metabolic acidosis stimulates expression of hypoxia-inducible factor (HIF)-1α-induced target genes such as stromal derived factor-1 and cathelicidin, an antimicrobial peptide. Since the collecting duct (CD) plays a pivotal

Hypoxia promotes production of neural crest cells in the embryonic head.

Deirdre Scully et al.

Development (Cambridge, England), 143(10), 1742-1752 (2016-05-18)

Hypoxia is encountered in either pathological or physiological conditions, the latter of which is seen in amniote embryos prior to the commencement of a functional blood circulation. During the hypoxic stage, a large number of neural crest cells arise from

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IOX2

≥98% (HPLC)

About This Item

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Eigenschaften

Qualitätsniveau

Assay

Form

Farbe

Löslichkeit

Lagertemp.

SMILES String

InChI

InChIKey

Verwandte Kategorien

Beschreibung

Anwendung

Biochem./physiol. Wirkung

Leistungsmerkmale und Vorteile

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Ähnliches Produkt

Sicherheitshinweise

Piktogramme

Signalwort

H-Sätze

P-Sätze

Gefahreneinstufungen

Lagerklassenschlüssel

WGK

Flammpunkt (°F)

Flammpunkt (°C)

Dokumentation

Analysenzertifikate (COA)

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