Pigment epithelium-derived factor (PEDF) is a 47kDa secreted glycoprotein that belongs to the non-inhibitory serpin family group. PEDF is widely expressed in adult and fetal tissues, including brain, spinal cord, plasma, bone, prostate, pancreas, heart and lung. PEDF acts as an angiogenesis inhibitor with neurotrophic, immunomodulation and antitumor properties. It functions as anti-angiogenic agent by counterbalancing the proangiogenic effect of VEGF. PEDF is one of the most abundant proteins released by adipocytes and induces insulin resistance in adipocytes and human skeletal muscle cells. Recently, it has been reported that PEDF is sufficient to maintain the self-renewal of pluripotent human embryonic stem cells.
物理的形状
凍結乾燥品(PBS)。
再構成
Reconstitute with 100 μL deionized water.
その他情報
Mouse PEDF (aa 20-417) is fused at the C-terminus to a FLAG®-tag.
法的情報
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany