SML2346

Ganciclovir

≥99% (HPLC), DMSO solution, viral DNA elongation inhibitor

• 別名: Ganciclovir ready made solution, 2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one, 9-(1,3-Dihydroxy-2-propoxymethyl)guanine, DHPG
• 実験式（ヒル表記法）: C₉H₁₃N₅O₄
• CAS番号: 82410-32-0
• 分子量: 255.23
• MDL番号: MFCD12197280
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 製品名: Ganciclovir ready made solution, ≥99% (HPLC), 10 mM in DMSO
• アッセイ: ≥99% (HPLC)
• フォーム: DMSO solution
• 濃度: 10 mM in DMSO
• 保管温度: 2-8°C
• SMILES記法: [n]1(c2[nH]c(n[c](c2nc1)=O)N)COC(CO)CO
• InChI: 1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
• InChI Key: IRSCQMHQWWYFCW-UHFFFAOYSA-N

詳細

アプリケーション

Ganciclovir ready-made solution has been used in combination with resveratrol to study its effect on melanoma cells.[1] It has also been used as a synthetic substrate for viral thymidine kinase to study its effects on human-inducible pluripotent stem cells.[2]

生物化学的／生理学的作用

Ganciclovir is a nucleoside guanosine analog that contains an active moiety, ganciclovir triphosphate. This active moiety can inhibit viral replication by interrupting the viral DNA during elongation.[3] Ganciclovir is a potent agent in preventing cytomegalovirus (CMV) retinitis disease in human immunodeficiency virus (HIV) patients. It exhibits therapeutic effects against CMV disease involving the lungs, liver, and gastrointestinal tract. Ganciclovir can be enzymatically phosphorylated to an active triphosphate analog by herpes simplex virus thymidine kinase (HSV-TK) or host-encoded deoxyguanosine kinase. [4] It has the potential to treat allogeneic bone marrow, kidney, heart, liver, and lung transplantations.[3]

その他情報

Ganciclovir ready made solution in DMSO is provided at 10mM concentration (2.55mg/mL). It is suggested to dilute the provided ready made solution to a working concentration of 2-100μM for cell culture applications.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H340
• 注意書き: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危険有害性の分類: Muta. 1B
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• 引火点(°F): 188.6 °F - closed cup
• 引火点(℃): 87 °C - closed cup