SML1635
Brassinin
≥98% (HPLC)
別名:
Brassinine, Methyl N-(1H-indol-3-ylmethyl)-carbamodithioate, N-(1H-indol-3-ylmethyl)-carbamodithioic acid methyl ester
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5 MG
￥16,000
25 MG
￥50,700
About This Item
実験式（ヒル表記法）:
C11H12N2S2
CAS番号:
分子量:
236.36
MDL番号:
UNSPSCコード:
12352200
PubChem Substance ID:
NACRES:
NA.77
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品質水準
アッセイ
≥98% (HPLC)
フォーム
powder
色
white to beige
溶解性
DMSO: 20 mg/mL, clear
保管温度
−20°C
SMILES記法
S=C(SC)NCC1=CNC2=C1C=CC=C2
InChI
1S/C11H12N2S2/c1-15-11(14)13-7-8-6-12-10-5-3-2-4-9(8)10/h2-6,12H,7H2,1H3,(H,13,14)
InChI Key
QYKQWFZDEDFELK-UHFFFAOYSA-N
生物化学的／生理学的作用
Brassinin is a phytoalexin isolated from cruciferous vegetables that exhibits anticancer, chemopreventive, antiproliferative and antifungal activities.
Brassinin is a phytoalexin isolated from cruciferous vegetables that exhibits anticancer, chemopreventive, antiproliferative and antifungal activities. In lung cancer cells, brassinin inhibits constitutive and IL-6-inducible STAT3 signaling through modulation of PIAS-3 and SOCS-3. It appears that brassinin induces apoptosis in PC-3 prostate cancer cells via the suppression of PI3K/Akt/mTOR/S6K1 signaling.
その他情報
air sensitive
保管分類コード
11 - Combustible Solids
WGK
WGK 3
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試験成績書（COA）
Lot/Batch Number
Bobin Kang et al.
The Journal of pharmacy and pharmacology, 72(9), 1245-1255 (2020-05-23)
The effects and molecular mechanisms of brassinin (BR), an indole phytoalexin from cruciferous vegetables, on monocyte-to-macrophage differentiation and inflammatory responses were investigated in this study. Inflammatory responses from RAW264.7 cells and THP-1 were stimulated by lipopolysaccharide (1 µg/ml), and monocyte-to-macrophage differentiation
Guillaume Quang N'Guyen et al.
Frontiers in plant science, 11, 611643-611643 (2021-02-09)
Alternaria brassicicola causes black spot disease in Brassicaceae. During host infection, this necrotrophic fungus is exposed to various antimicrobial compounds, such as the phytoalexin brassinin which is produced by many cultivated Brassica species. To investigate the cellular mechanisms by which
Taeyeon Hong et al.
Cells, 10(2) (2021-02-11)
Brassinin is a phytochemical derived from Chinese cabbage, a cruciferous vegetable. Brassinin has shown anticancer effects on prostate and colon cancer cells, among others. However, its mechanisms and effects on hepatocellular carcinoma (HCC) have not been elucidated yet. Our results
Andrea Angarita-Rodríguez et al.
Molecules (Basel, Switzerland), 25(1) (2019-12-28)
There is a continuous search for more reliable and effective alternatives to control phytopathogens through different strategies. In this context, indole-containing phytoalexins are stimuli-induced compounds implicated in plant defense against plant pathogens. However, phytoalexins' efficacy have been limited by fungal
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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