SML0808

JIB-04

≥98% (HPLC)

• 別名: (E)-N-(5-Chloro-pyridin-2-yl)-N′-(phenyl-pyridin-2-yl-methylene)-hydrazine
• 実験式（ヒル表記法）: C₁₇H₁₃ClN₄
• CAS番号: 199596-05-9
• 分子量: 308.76
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 10 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: Clc1cnc(cc1)N\N=C(\c3ncccc3)/c2ccccc2
• InChI: 1S/C17H13ClN4/c18-14-9-10-16(20-12-14)21-22-17(13-6-2-1-3-7-13)15-8-4-5-11-19-15/h1-12H,(H,20,21)/b22-17+
• InChI Key: YHHFKWKMXWRVTJ-OQKWZONESA-N

詳細

アプリケーション

JIB-04 has been used in sulforhodamine B cell growth assay.[1] It has also been used as a control to determine the inhibitory action of ML324 on KDM4A (histone lysine demethylase 4A).[2]

生物化学的／生理学的作用

JIB-04 is a selective inihibitor of Jumonji demethylases without inhibiting other α-ketoglutarate-dependent hydroxylases or histone-modifying enzymes including amine oxidase LSD1 (also known as KDM1A), which demethylates histone lysines. JIB-04 is a pan-inhibitor of Jumonji demethylases with JARID1A (KDM5A) being the most sensitive (IC₅₀=230 nM) followed by JMJD2D (IC₅₀=290 nM) and JMJD3 (KDM6B) and JMJD2C (KDM4C) more resistant (IC50 855 and 1100 nM, respectively). JIB-04 selectively inhibited viability of several human cancer cell lines with little toxicity towards normal cells, and also diminished tumor growth in two separate xenograft mouse models.

JIB-04 is a selective inihibitor of Jumonji demethylases.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable