Anti-p53 Antibody detects endogenous levels of total p53 protein.
TP53 gene is mapped to human chromosome 17p13.1.
免疫原
The antiserum was produced against synthesized peptide derived from human p53.
Immunogen Range: 283-332
生物化学的／生理学的作用
TP53 gene is involved in the regulation of cell cycle, senescence and apoptosis upon oncogene activation, stress and DNA damage. Therefore, the gene has anti-tumor activity initiation and prevents tumor progression. Mutation in TP53 is known to be the major cause of almost half of all human malignancy. Breast cancer is one such condition in which, the disease development is severe due to mutation in TP53 gene.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Wip1 phosphatase: between p53 and MAPK kinases pathways
Goloudina, AR
Oncotarget, 7(21), 31563?31571-31563?31571 (2016)
Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity
Sriraman A
Oncotarget, 7(22), 31623?31638-31623?31638 (2016)
Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy
Ridinger MS
PLoS ONE, 12(12), 1-22 (2017)
TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting
International journal of oncology, 52(5), 1380-1390 (2018-03-08)
Cancer has long been one of the most malignant diseases worldwide. Processes in cancer cells are often mediated by Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (p38 MAPK) and other signaling pathways. Traditional therapies are often problematic. Recently, a novel
