S5321

S15535

≥98% (HPLC), solid

• 別名: 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)-piperazine
• 実験式（ヒル表記法）: C₂₁H₂₄N₂O₂
• CAS番号: 146998-34-7
• 分子量: 336.43
• MDL番号: MFCD00911672
• UNSPSCコード: 12352200
• PubChem Substance ID: 329824452
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 色: white
• 溶解性: DMSO: ~6 mg/mL; H₂O: insoluble
• 保管温度: 2-8°C
• SMILES記法: C1COc2c(O1)cccc2N3CCN(CC3)C4Cc5ccccc5C4
• InChI: 1S/C21H24N2O2/c1-2-5-17-15-18(14-16(17)4-1)22-8-10-23(11-9-22)19-6-3-7-20-21(19)25-13-12-24-20/h1-7,18H,8-15H2
• InChI Key: QJPPEMXOOWNICQ-UHFFFAOYSA-N

詳細

アプリケーション

S15535 has been used as a serotonin 1A receptor (5-HT1A) agonist in zebrafish.[1]

S15535 may be used in histamine 5-HT_1A-medaited cell signaling studies.

生物化学的／生理学的作用

Potent, orally active, partial 5-HT_1A receptor agonist

S15535, a benzodioxane, is a selective but partial agonist of histamine serotonin 1A (5-HT_1A) receptor. It activates presynaptic 5-HT_1A receptors and suppresses the release of hippocampal 5-HT. It acts as an anxiolytic agent and modulates the cholinergic and cognitive function in rodents.[2]

安全性情報

• ピクトグラム: GHS09
• シグナルワード: Warning
• 危険有害性情報: H410
• 注意書き: P273 - P391 - P501
• 危険有害性の分類: Aquatic Acute 1 - Aquatic Chronic 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves