S2064

SC-560

≥98% (HPLC)

• 別名: 5-(4-クロロフェニル)-1-(4-メトキシフェニル)-3-トリフルオロメチルピラゾール
• 実験式（ヒル表記法）: C₁₇H₁₂ON₂ClF₃
• CAS番号: 188817-13-2
• 分子量: 352.74
• MDL番号: MFCD02179214
• UNSPSCコード: 51111800
• PubChem Substance ID: 24278696
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 溶解性: DMSO: >20 mg/mL
• 保管温度: 2-8°C
• SMILES記法: COc1ccc(cc1)-n2nc(cc2-c3ccc(Cl)cc3)C(F)(F)F
• InChI: 1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
• InChI Key: PQUGCKBLVKJMNT-UHFFFAOYSA-N
• 遺伝子情報: human ... PTGS1(5742) , PTGS2(5743)

詳細

アプリケーション

SC-560 has been used as a cyclooxygenase-1 (COX-1) inhibitor to study its effects on prostaglandin E-2 (PGE2) signaling in ciliogenesis in zebrafish embryos.[1] It has also been used as a selective inhibitor of COX-1 to study its role in PM10-induced endothelial dysfunction.[2]

生物化学的／生理学的作用

シクロオキシゲナ-ゼ-1 (COX-1) の選択的インヒビタ-であり、 COX-2と比較してCOX-1に700倍の選択性を示します。

SC-560 (5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole) is a non-steroidal anti-inflammatory drug (NSAID).[3] It is a lipophilic, diaryl heterocyclic compound.[4] SC-560 acts as an effective antiviral agent against hepatitis C virus (HCV).[5] It also has a potential to hinder prostaglandin E2 synthesis in neurons at nanomolar concentrations.[6]

SC-560 belongs to the diaryl heterocycle class of cyclooxygenase (COX) inhibitors. It exhibits anti-tumor and anti-proliferative activities.[7]

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves