P5514

ピリラミン マレイン酸塩

• 別名: N-(4-メトキシフェニル)メチル-N′,N′-ジメチル-N-(2-ピリジニル)-1,2-エタンジアミン マレイン酸塩, メピラミン マレイン酸塩
• 実験式（ヒル表記法）: C₁₇H₂₃N₃O · C₄H₄O₄
• CAS番号: 59-33-6
• 分子量: 401.46
• EC Number: 200-422-7
• MDL番号: MFCD00069333
• UNSPSCコード: 12352116
• PubChem Substance ID: 24277797
• NACRES: NA.77

特性

• 形状: powder
• オーガナイザー: Watson
• SMILES記法: OC(=O)\C=C/C(O)=O.COc1ccc(CN(CCN(C)C)c2ccccn2)cc1
• InChI: 1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChI Key: JXYWFNAQESKDNC-BTJKTKAUSA-N
• 遺伝子情報: human ... HRH1(3269)

詳細

アプリケーション

Pyrilamine maleate salt has been used:

• to treat Cassiopea sp. as H₁ receptor antagonist
• to intraperitoneally inject mice to prevent the release of endogenous histamine
• in membrane binding assay to determine the K_i values and in the comparative inhibitory concentration (IC₅₀) studies by whole-cell patch clamp technique

生物化学的／生理学的作用

Pyrilamine maleate is a H1 histamine receptor antagonist. Pyrilamine maleate induces sleep in vertebrates. In Cassiopea, it induces concentration dependent dormancy.

特徴および利点

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Watson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H315,H319,H335
• 注意書き: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves