P3755

6-プロピル-2-チオウラシル

enzyme inhibitor

• 別名: 4-ヒドロキシ-2-メルカプト-6-プロピルピリミジン
• 実験式（ヒル表記法）: C₇H₁₀N₂OS
• CAS番号: 51-52-5
• 分子量: 170.23
• Beilstein: 130039
• EC Number: 200-103-2
• MDL番号: MFCD00006041
• UNSPSCコード: 41106305
• PubChem Substance ID: 24898446
• NACRES: NA.51

特性

• 詳細: enzyme inhibitor
• アッセイ: ≥99% (HPLC)
• 形状: powder
• mp: 218-220 °C (lit.)
• 溶解性: 10% NH₃: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
• SMILES記法: CCCC1=CC(=O)NC(=S)N1
• InChI: 1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
• InChI Key: KNAHARQHSZJURB-UHFFFAOYSA-N
• 遺伝子情報: human ... DIO1(1733) , TPO(7173)

詳細

詳細

6-Propyl-2-thiouracil or 6-n-Propylthiouracil (PROP) is a compound with a bitter taste.

アプリケーション

6-Propyl-2-thiouracil (PROP) has been used to impregnate on disk for PROP taster status studies for sensory characterization in a defined human sample group. It has been used as a screening agent for testing the intensity of taste by labeled magnitude scale (LMS).

6-Propyl-2-thiouracil is a thyreostatic (thyroid hormone) agent that may be used as a reference material in thyreostatic drug separation and detection technologies such as capillary electrophoresis, high performance liquid chromatography (HPLC), or gas chromatography.

生物化学的／生理学的作用

6-Propyl-2-thiouracil (6-PTU), a potential inhibitor of D1 iodothyronine deiodinase, is involved in the deiodination of iodothyronines. It is an uncompetitive inhibitor of iodothyronine substrates.

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H351
• 注意書き: P201 - P301 + P312 + P330 - P308 + P313
• 危険有害性の分類: Acute Tox. 4 Oral - Carc. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type P3 (EN 143) respirator cartridges