L7035

clasto-ラクタシスチン β-ラクトン

• 別名: (1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-Oxa-2-Azabicyclo[3.2.0]Heptane-3,7-Dione, Omuralide
• 実験式（ヒル表記法）: C₁₀H₁₅NO₄
• CAS番号: 154226-60-5
• 分子量: 213.23
• MDL番号: MFCD01076526
• UNSPSCコード: 12352200
• PubChem Substance ID: 24896450
• NACRES: NA.77

特性

• アッセイ: ≥95% (HPLC)
• 品質水準: 100
• 形状: film
• 溶解性: DMSO: soluble 25 mg/mL
• 保管温度: −20°C
• SMILES記法: [H][C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2C)[C@@H](O)C(C)C
• InChI: 1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1
• InChI Key: FWPWHHUJACGNMZ-NBBQQVJHSA-N

詳細

アプリケーション

Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.

Clasto-Lactacystin β-lactone has been used as a protein degradation inhibitor to test its effect on memory improvements in mice. It has also been used as a proteasome inhibitor in human ovarian surface epithelium (HOSE) cells and dendritic cells (DCs).

生物化学的／生理学的作用

細胞透過性の不可逆的プロテオソ-ムインヒビタ-です。ラクタシスチンは、clasto-ラクタシスチンβ-ラクトンの前駆体として作用します。

Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii by acting in the N-threonine residue of the  β -type subunits.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H319
• 注意書き: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable