I134

L-N⁵-(1-Iminoethyl)ornithine hydrochloride

≥95% (HPLC)

• 別名: L-NIO hydrochloride, L-Ornithine ψ-acetamidine hydrochloride
• 実験式（ヒル表記法）: C₇H₁₅N₃O₂ · xHCl
• CAS番号: 852173-80-9
• 分子量: 173.21 (free base basis)
• MDL番号: MFCD00153817
• UNSPSCコード: 12352204
• PubChem Substance ID: 329815348
• NACRES: NA.26

特性

• アッセイ: ≥95% (HPLC)
• フォーム: powder
• 分子量: calculated mol wt 173.22 g/mol
• 保管条件: desiccated; under inert gas
• 色: white to beige
• 溶解性: H₂O: 2 mg/mL, clear (warmed)
• 保管温度: −20°C
• SMILES記法: CC(NCCC[C@H](N)C(O)=O)=N.[H]Cl
• InChI: 1S/C7H15N3O2.ClH/c1-5(8)10-4-2-3-6(9)7(11)12;/h6H,2-4,9H2,1H3,(H2,8,10)(H,11,12);1H/t6-;/m0./s1
• InChI Key: JIBZSGQTCBWUKL-RGMNGODLSA-N

詳細

アプリケーション

L-N⁵-(1-Iminoethyl) ornithine hydrochloride has been used to study the effects of the cytotoxic drug paclitaxel and carbachol (a cholinergic agonist) to induce death in breast tumor MCF-7 cells and the role of nitric oxide synthase (NOS) in this effect.[1] It has also been used to study its effects on pulmonary arterial responses to sufentanil in the feline pulmonary vascular bed.[2][3]

生物化学的／生理学的作用

A potent irreversible inhibitor of nitric oxide synthase.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves