H7041

インターロイキン-2 ヒト

IL-2, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin tested

• 別名: T細胞増殖因子, インターロイキン-2
• MDL番号: MFCD00165721
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 由来生物: human
• 品質水準: 100
• リコンビナント: expressed in HEK 293 cells
• 形状: lyophilized powder
• 有効性: ≤5.0 ng/mL ED₅₀
• 品質: endotoxin tested
• 分子量: monomer 15 kDa (glycosylated)
• 包装: pkg of 5X10 μg; pkg of 10 μg; pkg of 100 μg
• テクニック: cell culture | mammalian: suitable
• UniProtアクセッション番号: P60568
• 保管温度: −20°C
• 遺伝子情報: human ... IL2(3558)

詳細

詳細

Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor.

アプリケーション

Interleukin-2 human has been used to culture peripheral blood mononuclear cells (PBMC). It has been used to activate effector cell (PBMC) and to study antibody-dependent cell-mediated cytotoxicity.

生物化学的／生理学的作用

Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages. It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the formation and essential functions of regulatory T cells. It is implicated in autoimmune disease. IL-2 is associated with apoptosis and thus, possesses antitumor response. IL-2 mediates CD41⁺ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.

インターロイキン-2（IL-2）は、特定のTリンパ球サブセットによって産生される免疫調節因子です。このリンホカインは、活性化T細胞やその関連細胞の長期の増殖を促進します。IL-2は、NK細胞の活性化および増殖において役割を担っており、インターフェロンγやB細胞成長因子の分泌を誘導し、IL-2受容体の発現を調節します。

調製ノート

Human Interleukin-2 (IL-2) expressed in human HEK 293 cells is a glycosylated monomer with a molecular mass of 15 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

アナリシスノート

The specific activity was determined by the dose-dependent stimulation of the proliferation of mouse CTLL-2 cells (mouse cytotoxic T cell line).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable