E1253

エストリオール

≥97%

• 別名: 1,3,5(10)-エストラトリエン-3,16α,17β-トリオール, 16α-ヒドロキシエストラジオール, 3,16α,17β-トリヒドロキシ-1,3,5(10)-エストラトリエン
• 実験式（ヒル表記法）: C₁₈H₂₄O₃
• CAS番号: 50-27-1
• 分子量: 288.38
• Beilstein: 2508172
• EC Number: 200-022-2
• MDL番号: MFCD00003691
• UNSPSCコード: 51111800
• PubChem Substance ID: 24894396
• NACRES: NA.77

特性

• 由来生物: synthetic (organic)
• 無菌性: non-sterile
• アッセイ: ≥97%
• 形状: powder
• mp: 280-282 °C (lit.)
• 溶解性: pyridine: 50 mg/mL, clear, colorless to faintly brownish-yellow
• 輸送温度: ambient
• 保管温度: room temp
• SMILES記法: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1C[C@@H](O)[C@@H]2O
• InChI: 1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
• InChI Key: PROQIPRRNZUXQM-ZXXIGWHRSA-N
• 遺伝子情報: human ... SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Ar(24208)

詳細

アプリケーション

Estriol has been used as a sex hormone to determine its binding constants to insulin (INS), the insulin receptor (IR), and INS-like peptides derived from the IR.

生物化学的／生理学的作用

Estriol is a metabolite of 17β-estradiol with much lower biological activity. It is the primary estrogen found in the urine. Large quantities of estriol and estrone are produced by the placenta during pregnancy. These are also the primary estrogens produced by adipose tissue in men and post-menopausal women. Estriol may exhibit immunomodulatory benefits against various diseases such as autoimmune, inflammatory, and neurodegenerative conditions.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H351,H360FD,H362
• 注意書き: P201 - P202 - P260 - P263 - P264 - P308 + P313
• 危険有害性の分類: Carc. 2 - Lact. - Repr. 1A
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 個人用保護具 (PPE): Eyeshields, Gloves, type P3 (EN 143) respirator cartridges