C6427

Clindamycin 2-phosphate

aminoglycoside antibiotic

• 別名: Clindamycin 2-dihydrogen phosphate
• 実験式（ヒル表記法）: C₁₈H₃₄ClN₂O₈PS
• CAS番号: 24729-96-2
• 分子量: 504.96
• EC Number: 246-433-0
• MDL番号: MFCD07793328
• UNSPSCコード: 51102829
• PubChem Substance ID: 24892866
• NACRES: NA.76

特性

• フォーム: solid
• 溶解性: DMSO: 224 mg/mL at 25 °C
• 抗生物質活性スペクトル: Gram-positive bacteria
• 作用機序: protein synthesis | interferes
• 保管温度: 2-8°C
• SMILES記法: CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC([C@H](C)Cl)C2O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]2O
• InChI: 1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12?,13+,14-,15?,16+,18+/m0/s1
• InChI Key: UFUVLHLTWXBHGZ-MWBQRTRKSA-N

詳細

詳細

Chemical structure: macrolide

アプリケーション

Clindamycin 2-phosphate is an aminoglycoside antibiotic that has been used to study the cytoxicity of antibiotics on human cell lines [1], Bacterial protein synthesis and peptide translation, and the inhibition of human Tyrosyl-DNA Phosphodiesterase [2].

生物化学的／生理学的作用

Clindamycin 2-phosphate is a pharmacological tyrosyl-DNA phosphodiesterase (Tdp1) inhibitor. Clindamycin 2-phosphate can repair DNA topoisomerase I-DNA covalent complexes by hydrolyzing the tyrosyl-DNA bond. It inhibits protein synthesis in bacteria by binding the 50s ribosomal subunit. [2]. Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.

Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.

その他情報

リコサミドクラスの抗菌性および抗原虫性の抗生物質です。

Keep container tightly closed in a dry and well-ventilated place.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H317,H319,H362
• 注意書き: P260 - P263 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Lact. - Skin Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves