B133

(S)-(−)-Bay K8644

≥98% (HPLC), solid

• 別名: S-(−)-1,4-ジヒドロ-2,6-ジメチル-5-ニトロ-4-[2-(トリフルオロメチル)フェニル]-3-ピリジンカルボン酸メチルエステル
• 実験式（ヒル表記法）: C₁₆H₁₅F₃N₂O₄
• CAS番号: 98625-26-4
• 分子量: 356.30
• MDL番号: MFCD00153769
• UNSPSCコード: 12352200
• PubChem Substance ID: 24891582
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• 色: yellow
• 溶解性: H₂O: slightly soluble; ethanol: soluble (Organic solutions are stable for at least 20 days at RT.)
• 保管温度: 2-8°C
• SMILES記法: COC(=O)C1=C(C)NC(C)=C([C@H]1c2ccccc2C(F)(F)F)[N+]([O-])=O
• InChI: 1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1
• InChI Key: ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
• 遺伝子情報: human ... ADORA3(140) ; rat ... Adora1(29290) , Adora2a(25369)

詳細

詳細

(S)-(-)-Bay K8644, a dihydropyridine compound is a Ca²⁺ channel activator. It is an enantiomer of Bay K 8644.

アプリケーション

(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmia in rats.

生物化学的／生理学的作用

(S)-(-)-Bay K8644 enhances Ca²⁺ current, whereas the (+)-Bay K 8644 is a weak Ca²⁺ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions.

特徴および利点

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法的情報

Manufactured and sold with the permission of Bayer AG.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319
• 注意書き: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves