A2487

コトリモキサゾール

100 mg/mL in DMSO

• 別名: トリメトプリム-スルファメトキサゾール, TMP-SMX
• 実験式（ヒル表記法）: C₁₄H₁₈N₄O₃ · 5 C₁₀H₁₁N₃O₃S
• CAS番号: 8064-90-2
• 分子量: 1556.71
• UNSPSCコード: 51102829
• NACRES: NA.85

特性

• 形状: liquid
• 品質水準: 200
• 濃度: 100 mg/mL in DMSO
• 色: colorless to faint yellow
• 抗生物質活性スペクトル: Gram-negative bacteria; Gram-positive bacteria; fungi; parasites
• 作用機序: DNA synthesis | interferes
• 輸送温度: dry ice
• 保管温度: −20°C
• InChI: 1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)
• InChI Key: WZRJTRPJURQBRM-UHFFFAOYSA-N

詳細

アプリケーション

Cotrimoxazole has been used as an antimicrobial agent.

生物化学的／生理学的作用

Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.

包装

1ml

調製ノート

prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

その他情報

Keep container tightly closed in a dry and well-ventilated place.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Warning
• 危険有害性情報: H361fd,H412
• 注意書き: P202 - P273 - P280 - P308 + P313 - P405 - P501
• 危険有害性の分類: Aquatic Chronic 3 - Repr. 2
• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable