A0384

Arcaine sulfate salt

• 別名: 1,4-Diguanidinobutane sulfate salt
• 実験式（ヒル表記法）: C₆H₁₆N₆ · H₂O₄S
• CAS番号: 14923-17-2
• 分子量: 270.31
• MDL番号: MFCD00050545
• UNSPSCコード: 12352200
• PubChem Substance ID: 24277954
• NACRES: NA.77

特性

• 由来生物: synthetic (organic)
• 品質水準: 200
• アッセイ: ≥98% (TLC)
• フォーム: powder
• mp: >280 °C
• 溶解性: 1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• SMILES記法: OS(O)(=O)=O.NC(=N)NCCCCNC(N)=N
• InChI: 1S/C6H16N6.H2O4S/c7-5(8)11-3-1-2-4-12-6(9)10;1-5(2,3)4/h1-4H2,(H4,7,8,11)(H4,9,10,12);(H2,1,2,3,4)
• InChI Key: RWTGFMPOODRXIM-UHFFFAOYSA-N
• 遺伝子情報: human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907)

詳細

アプリケーション

Arcaine sulfate salt has been used as an N-methyl-d-aspartate (NMDA) receptor effector/antagonist:

• to evaluate its effects on the acquisition of electrical kindling of the amygdala[1]
• to compare its effects with agmatine and MK801 on NMDA- or glutamate-induced neuronal damage[2]
• to study its effects on cell-free translation of synthetic polynucleotide[3]

生物化学的／生理学的作用

Arcaine sulfate salt (1,4-diguanidinobutane), a polyamine,[3] is an antagonist of the polyamine binding site of the N-methyl-d-aspartate (NMDA) receptor.[4] Arcaine, an agmatine analog,[2] along with ifenprodil, might have a possibility for therapeutic management in epileptic disorders.[1]

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)