SBR00026

Ligstroside

Nitric oxide inhibitor, ≥95%

• 別名: (-)-ligstroside, Ligustroside
• 実験式（ヒル表記法）: C₂₅H₃₂O₁₂
• CAS番号: 35897-92-8
• 分子量: 524.51
• UNSPSCコード: 12352200
• NACRES: NA.25

特性

• 由来生物: plant
• 品質水準: 100
• アッセイ: ≥95%
• フォーム: lyophilized powder
• 分子量: 524.51
• 溶解性: DMSO: ≥10 mg/mL (19 mM); methanol: ≥10 mg/mL
• アプリケーション: metabolomics; vitamins, nutraceuticals, and natural products
• 保管温度: −20°C
• InChI: 1S/C25H32O12/c1-3-15-16(10-19(28)34-9-8-13-4-6-14(27)7-5-13)17(23(32)33-2)12-35-24(15)37-25-22(31)21(30)20(29)18(11-26)36-25/h3-7,12,16,18,20-22,24-27,29-31H,8-11H2,1-2H3/b15-3+/t16-,18+,20+,21-,22+,24-,25-/m0/s1
• InChI Key: GMQXOLRKJQWPNB-MVVLSVRYSA-N

詳細

詳細

Ligstroside, also known as ligusroside, is a secoiridoid glycoside, a bioactive natural compound commonly derived from plants like Ligustrum lucidum, Jasminum officinale, and Osmanthus heterophyllus. Existing research suggests that this metabolite functions as an nitric oxide inhibitor and may exhibit diverse biological activities, including anti-neoplastic, antioxidant, antiviral, and anti-inflammatory properties.

アプリケーション

Ligstroside is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

生物化学的／生理学的作用

Ligstroside is a natural product derived from leaves of Olea europaea. Ligstroside displays several potentially beneficial anti-inflammatory properties by exhibiting selective inhibition effect on COX-1 enzyme of arachidonate cascade metabolism. Ligstroside generates a reduction of the PGE₂ (prostaglandin E₂) levels in activated mouse macrophage (IC50 = 48.53 μM) and also reduction of the TXB₂ (thromboxane B₂) levels in human platelets (IC50 = 122.63 μM).^[1] Moreover, Ligstroside exhibits inhibition activity of NO production in LPS-activated RAW264.7 macrophages (17.8% at 30 μM and 40.7% at 100 μM) without any cytotoxic effect in these cells.^[2],[3] Additionally, Ligstroside exhibits in vitro antiviral activity against parainfluenza type 3 virus (IC50 = 15.6 μM).^[4]

特徴および利点

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

保管および安定性

Hygroscopic; store in dry place with desiccant

その他情報

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安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable