2106

ヘパリン ナトリウム塩 from porcine intestinal mucosa

endotoxin, free

• CAS番号: 9041-08-1
• MDL番号: MFCD00081689
• UNSPSCコード: 12352201
• NACRES: NA.21

特性

• 由来生物: Porcine intestinal mucosa
• 品質水準: 200
• フォーム: powder
• 使用法: sufficient for 5 mL blood anticoagulant
• 包装: preweighed vial of 300 USP units
• 不純物: endotoxin, free
• 色: beige
• 溶解性: water: soluble 50 g/L; acetone: insoluble; alcohol: insoluble; benzene: insoluble; chloroform: insoluble; diethyl ether: insoluble
• 適合性: for use with E-Toxate^™
• 保管温度: room temp
• SMILES記法: [Na+].[S](=O)(=O)(NC1C(OC(C(C1O[S](=O)(=O)O)OC4OC(C(C(C4O[S](=O)(=O)O)O)O)C(=O)O)CO)OC2C(OC(C(C2O)O[S](=O)(=O)O)OC3C(OC(C(C3O)NC(=O)C)O)CO[S](=O)(=O)O)C(=O)O)O
• InChI: 1S/C26H42N2O37S5.Na/c1-4(30)27-7-9(31)13(6(56-23(7)39)3-55-67(43,44)45)58-26-19(65-70(52,53)54)12(34)16(20(62-26)22(37)38)60-24-8(28-66(40,41)42)15(63-68(46,47)48)14(5(2-29)57-24)59-25-18(64-69(49,50)51)11(33)10(32)17(61-25)21(35)36;/h5-20,23-26,28-29,31-
• InChI Key: JRTRSJGZMRQDHI-UHFFFAOYSA-N

詳細

アプリケーション

Heparin sodium salt from porcine intestinal mucosa has been used as a M199 medium supplement used for maintaining human umbilical vein endothelial cells.[1]

生物化学的／生理学的作用

Heparin sodium salt is the salt form of heparinic acid and is a polymer classified as a mucopolysaccharide or a glycosoaminoglycan. It is an anticoagulant that produces its major anticoagulant effect by activating antithrombin. Heparin binds to antithrombin III, a naturally occurring plasma protease inhibitor and accelerates significantly the rate at which antithrombin III (AT-III) inhibits coagulation proteases (factor Xa and thrombin).[2][3][4] Additionally, it also facilitates the stabilization and regulation of tryptase as an enzymatically active tetramer.[5]

注意

注射用ではありません。

その他情報

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

法的情報

E-Toxate is a trademark of Sigma-Aldrich Co. LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)