513030

PD 169316

A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM).

• 別名: PD 169316, 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
• 実験式（ヒル表記法）: C₂₀H₁₃FN₄O₂
• CAS番号: 152121-53-4
• 分子量: 360.34
• MDL番号: MFCD12405019
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: orange-yellow
• 溶解性: DMSO: 10 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: Fc1ccc(cc1)c2nc([nH]c2c4ccncc4)c3ccc(cc3)[N+](=O)[O-]
• InChI: 1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
• InChI Key: BGIYKDUASORTBB-UHFFFAOYSA-N

詳細

詳細

A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
p38 MAP kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 89 nM against p38 MAP kinase

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

その他情報

Nath, R., et al. 2001. Cell Mol. Biol. Lett.6, 173.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06,GHS05
• シグナルワード: Danger
• 危険有害性情報: H301,H315,H318,H335
• 注意書き: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable