492000-M

NOX Inhibitor III, VAS2870

The NOX Inhibitor III, VAS2870, also referenced under CAS 722456-31-7, controls the biological activity of NOX.

• 別名: NOX Inhibitor III, VAS2870, 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, NADPH Oxidase Inhibitor III, VAS2870
• 実験式（ヒル表記法）: C₁₈H₁₂N₆OS
• CAS番号: 722456-31-7
• 分子量: 360.39
• MDL番号: MFCD03407188
• UNSPSCコード: 12352200

特性

• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: tan
• 溶解性: DMSO: 25 mg/mL
• 保管温度: 2-8°C

詳細

詳細

A cell-permeable thiotriazolopyrimidine compound that acts as an effective NADPH oxidase (NOX) inhibitor (IC₅₀ = 10.6 µM against NOX activity in human neutrophil lysates) and is widely used for studying NOX-dependent cellular ROS formations in various cultures, including oxLDL-treated HUVEC (complete inhibition at 5 µM), PDGF-induced primary rat VSMC (vascular smooth muscle cells; complete inhibition at 10 µM), as well as aortic sections from spontaneously hypertensive rats (SHRs) (72% inhibition at 10 µM). Also shown to inhibit PDGF-BB-induced murine EB (embryonid body) vacularization (74% inhibition at 50 µM) and improve ACh-induced vasorelaxation of isolated rat aortic rings from both SHRs and non-hypertensive rats ex vivo (by 41.7 and 34.5%, respectively, at 10 µM).

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Wind, S., et al. 2010. Hypertension56, 490.
Lange, S., et al. 2009. Cardiovasc. Res.81, 159.
Stielow, C., et al. 2006. Biochem. Biophys. Res. Commun.344, 200.
ten Freyhaus, H., et al. 2006. Cardiovasc. Res.71, 331.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable