480415

NF023

A suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the Go/Gi group (EC₅₀ ~ 300 nM).

• 別名: NF023, 8,8ʹ-[Carbonylbis(imino-3,1-phenylene)]bis-(1,3,5-naphthalenetrisulfonic Acid), 6Na, P2X Antagonist I, Purinergic Receptor P2X Antagonist I
• 実験式（ヒル表記法）: C₃₅H₂₀N₄O₂₁S₆ · 6Na
• 分子量: 1162.88
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white to off-white
• 溶解性: water: soluble
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

A suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the G_o/G_i group (EC₅₀ ~ 300 nM). Suppresses GTPγS binding to recombinant G-protein α-subunits. Acts by inhibiting the formation of the agonist-specific ternary complex (agonist/receptor/G-protein). NF023 does not interfere with the interaction between α-subunits and βγ-dimer but competes with the effector binding site. Also a P2X receptor antagonist (IC₅₀ = 240 nM for P2X1; 8.5 µM for P2X3 receptor in rat muscle). Causes a concentration dependent inhibition of excitatory junction potentials (IC₅₀ = 4.8 pM).

生物化学的／生理学的作用

Cell permeable: no

Primary Target
α-subunits of the Go/Gi group of G-protein

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 240 nM for P2X1; 8.5 µM for P2X3 receptor in rat muscle; 4.8 pM in the inhibition of excitatory junction potentials; EC50 ~ 300 nM as G-protein antagonist for α-subunits of the Go/Gi group

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.

その他情報

Snedden, P., et al. 2000. Br. J. Pharmacol.129, 1089.
Soto, F., et al. 1999. Neuropharmacology38, 141.
Beindle, W., et al. 1996. Mol. Pharmacol.50, 415.
Freissmuth, M., et al. 1996. Mol. Pharmacol.49, 602.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable