420128

JNK Inhibitor II

InSolution, ≥98%

• 別名: InSolution JNK Inhibitor II
• 実験式（ヒル表記法）: C₁₄H₈N₂O
• 分子量: 220.23
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: yellow-brown
• 輸送温度: wet ice
• 保管温度: −20°C

詳細

詳細

A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC₅₀ = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
JNK 1, JNK 2, JNK 3

Product competes with ATP.

Reversible: yes

Target IC₅₀: 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

物理的形状

A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO.

再構成

Following initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage.

その他情報

Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA98, 13681.
Han, Z., et al. 2001. J. Clin. Invest.108, 73.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• 引火点(℃): 87 °C - closed cup - (Dimethylsulfoxide)