260920

DNA Methyltransferase Inhibitor

The DNA Methyltransferase Inhibitor, also referenced under CAS 32675-71-1, controls the biological activity of DNA Methyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 別名: DNA Methyltransferase Inhibitor, 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propionic acid, RG108, DNA MTase Inhibitor I
• 実験式（ヒル表記法）: C₁₉H₁₄N₂O₄
• CAS番号: 32675-71-1
• 分子量: 334.33
• MDL番号: MFCD00379702
• UNSPSCコード: 12352200
• NACRES: NA.54

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 有効性: 115 nM IC₅₀
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow
• 溶解性: DMSO: 100 mg/mL; methanol: soluble
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: [nH]1c2c(c(c1)CC(N3C(=O)c4c(cccc4)C3=O)C(=O)O)cccc2
• InChI: 1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)
• InChI Key: HPTXLHAHLXOAKV-UHFFFAOYSA-N

詳細

詳細

A cell-permeable, specific DNA methyltransferases inhibitor (IC₅₀ = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
CPG methylase M.Sssl

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Brueckner, B., et al. 2005. Cancer Res.65, 6305.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable