178278

Apigenin

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM).

• 別名: Apigenin, 4ʹ,5,7-Trihydroxyflavone
• 実験式（ヒル表記法）: C₁₅H₁₀O₅
• CAS番号: 520-36-5
• 分子量: 270.24
• MDL番号: MFCD00006831
• UNSPSCコード: 12352212
• NACRES: NA.77

特性

• 品質水準: 100
• 詳細: Merck USA index - 14, 730
• アッセイ: ≥98% (HPLC)
• フォーム: crystalline solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: yellow
• 溶解性: hot ethanol: 1 mg/mL; DMSO: 10 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: [o]1c2c([c](cc1c3ccc(cc3)O)=O)c(cc(c2)O)O
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
• InChI Key: KZNIFHPLKGYRTM-UHFFFAOYSA-N

詳細

詳細

A plant flavonoid that reverses the transformed phenotypes of various ras-transformed cells, apparently due to inhibition of mitogen activated protein (MAP) kinase-associated signal transduction pathways. Treatment of v-H-ras-transformed NIH 3T3 cells with apigenin (12.5 µM) has been shown to induce dephosphorylation of p44^mapk and reduction in MAP kinase activity. Has also been reported to inhibit the proliferation of malignant tumor cells by G₂/M arrest and to induce morphological differentiation.

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM). This finding has been attributed to the inhibition of MAP kinase activity. Inhibits the proliferation of malignant tumor cells by G₂/M arrest and induces morphological differentiation.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
MAP kinase

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Irritant (B)

再構成

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C.

その他情報

Kuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun.212, 767.
Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
Kuo, M.L., et al. 1994. Cancer Lett.87, 91.
Sato, F., et al. 1994. Biochem. Biophys. Res. Commun.204, 578.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3