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D4902

デキサメタゾン

powder, BioReagent, suitable for cell culture, ≥97%

Dexamethasone

別名:

(11β,16α)-9-フルオロ-11,17,21-トリヒドロキシ-16-メチルプレグナ-1,4-ジエン-3,20-ジオン, 9α-フルオロ-16α-メチル-11β,17α,21-トリヒドロキシ-1,4-プレグナジエン-3,20-ジオン, 9α-フルオロ-16α-メチルプレドニゾロン, プレドニゾロンF

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あなたへ/カタログ番号在庫状況単価
25 mg

在庫あり出荷可能from市川市大町368

￥8,860
100 mg

在庫あり出荷可能from市川市大町368

￥9,060
500 mg

在庫あり出荷可能from市川市大町368

￥49,400
1 g

在庫あり出荷可能from市川市大町368

￥87,300

この商品について

実験式（ヒル表記法）:
C22H29FO5
CAS番号:
50-02-2
分子量:
392.46
UNSPSC Code:
12352209
NACRES:
NA.75
PubChem Substance ID:
24893906
EC Number:
200-003-9
Beilstein/REAXYS Number:
2066651
MDL number:
MFCD00064136
Biological source:
synthetic
Form:
powder
Assay:
≥97%

￥8,860

在庫あり出荷可能詳細

​
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biological source

synthetic

Quality Segment

200

product line

BioReagent

assay

≥97%

form

powder

potency

4-500 ng/mL

technique(s)

cell culture | mammalian: suitable, single cell analysis: suitable

mp

262-264 °C (lit.)

solubility

methanol: 25 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

Gene Information

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Application

デキサメタゾンは、アポトーシス、細胞のシグナル経路、細胞の分化[1]、および遺伝子発現の研究に使用されます。

Biochem/physiol Actions

グルココルチコイド・抗炎症剤。T細胞の生存、成長、分化を調節します。一酸化窒素合成酵素の誘導を阻害します。
グルココルチコイド抗炎症薬です。
体内で代謝され難く、高い親和性とバイオアベイラビリティを持っています。

Packaging

底の開いたガラス瓶内容物は内部に挿入され接着された円錐部に入っています。

Physical form

粉末2～8°C保存。ストック溶液は分注して凍結保存し、凍結融解の繰り返しは避けてください。

Preparation Note

20 μg/mLのストック溶液を調製するには、本製品1 mgに対して無水エタノ-ル1 mLを添加し、穏やかに撹拌して溶解させます。添加したエタノ-ル1 mLに対して滅菌培地49 mLを撹拌しながら加え、最終濃度を20 μg/mLとします。

類似品目との比較

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相違点を表示

1 of 1

当該品目
D1756D918446165
デキサメタゾン powder, BioReagent, suitable for cell culture, ≥97%

Sigma-Aldrich

D4902

デキサメタゾン

デキサメタゾン ≥98% (HPLC), powder

Sigma-Aldrich

D1756

デキサメタゾン

デキサメタゾン meets USP testing specifications

Sigma-Aldrich

D9184

デキサメタゾン

デキサメタゾン VETRANAL®, analytical standard

Supelco

46165

デキサメタゾン

biological source

synthetic

biological source

-

biological source

synthetic (organic)

biological source

-

assay

≥97%

assay

≥98% (HPLC)

assay

97.0-102.0%

assay

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

product line

BioReagent

product line

-

product line

-

product line

VETRANAL®

technique(s)

cell culture | mammalian: suitable, single cell analysis: suitable

technique(s)

-

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

form

powder

form

powder

form

solid

form

-

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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質問

1–10/20 質問  

  1. Dear Customer support, Is this product  Dexamethasone, cat #D4902  suitable for in vivo use (mice treatment)?

    1 回答

    1. While we do not conduct in-house testing on these DMSO products in animals, there are numerous research papers available online documenting the utilization of this compound in animal studies. These papers serve as valuable resources for understanding the compound's effects and potential applications in various animal models:

      eNeuro. 2016 Mar-Apr; 3(2): ENEURO.0133-15.2016.
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819286/
      Mice were injected with carprofen (5 mg/kg, s.c.; catalog #024751, Butler Schein Animal Health) and dexamethasone (40 mg/kg, i.m.; catalog #D4902, Sigma-Aldrich) prior to surgery.

      https://www.google.com/search?q=D4902+mg%2Fkg+mice&rlz=1C1GCEA_enUS976US976&oq=D4902+mg%2Fkg+mice&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIHCAEQIRigATIHCAIQIRigATIHCAMQIRigATIHCAQQIRigATIHCAUQIRigAdIBCDg3ODJqMGo3qAIAsAIA&sourceid=chrome&ie=UTF-8&sei=VudraPqaJO6t5NoPvZyokQw

      役に立ちましたか？

  2. Two questions: 1. How to store 1mg/ml solution and how stable? 2. Is it advisable to filter working solution 20ug/ml with 0.22 um prior to use?

    1 回答

    1. This product is stable for approximately 5 years in powder form with the vial unopened. It is guaranteed for 1 year from the date of shipment. The stability upon reconstitution has not been determined. However, for a similar product, it is recommended to aliquot and freeze at -20°C after reconstitution. Stock solutions are stable for up to 2 months at -20°C and should be protected from light. Degradation occurs gradually and depends on exposure frequency and intensity. Discolored, cloudy, or particulate-containing solutions should be discarded. Solutions can be sterile filtered using a 0.22 µm membrane, as the powders are not sterile.

      役に立ちましたか？

  3. Hello,  I prepared a solution of Dexamethasone in DMSO and PBS for IP injection in mice for 20 days daily. Is it okay to store the solution at 4°C?

    1 回答

    1. Dexamethasone solutions in DMSO are stable for at least 30 days when stored at 4 °C and protected from light. Do not dilute to working concentrations in an aqueous buffer or medium until ready to use.

      役に立ちましたか？

  4. Can I store D4902 at -80°C? If I store it at -80°C instead of -20°C, can I use it stably for more than 2 months?

    1 回答

    1. Long-term solution stability studies have not been performed on this material. The impact of stability at -80°C has not been determined. However, an analytical standard available at 1 mg/mL in methanol, as product D-085, has a shelf life of 4 years when stored at -20°C. In addition, therapeutic preparations of Dexamethasone 3.3 mg/mL for injection manufactured by Hospira, list a shelf life of 24 months at -20°C. This product, in solution, may demonstrate similar stability.

      役に立ちましたか？

  5. What is the solubility of D4902 (Dexamethasone) in DMSO and ethanol? Additionally, how should stock solutions be stored?

    1 回答

    1. The solubility of D4902 (Dexamethasone) in ethanol is 25 mg/ml and DMSO is 25 mg/ml. Dexamethasone is insoluble in water. Stock solutions are stable for up to 2 months at -20°C.

      役に立ちましたか？

  6. IF Dexamethasone solutions forgrt to protected from light, what will happen in these solutions?

    1 回答

    1. Prepared solutions of Dexamethasone should be protected from light. Degradation occurs gradually and is dependent on the frequency and intensity of exposure. Solutions that appear discolored, cloudy, or contain particulates should be discarded. Unfortunately, there is not way to determine the degree of decomposition.

      役に立ちましたか？

  7. I read that the dexamethasone is packaged in a bottomless glass bottle, in an inserted fused cone. Is this cone sealed with a rubber lid to be able to safely open the bottle and dissolve all contents before fully opening the bottle?

    1 回答

    1. Please see the attached images of the vial and cap used to package this product. The cap is a screw-type and does not include a septum. Threading secures the inner cone to the outer vial.

      役に立ちましたか？

  8. what are different between D4902 and D1756? and if the same the both, why D4902 is descriptive about 'suitable for cell culture'?

    1 回答

    1. Product D4902 and D1756 are identical compounds, but are tested differently. Product D4902 is tested specifically for suitability in cell culture applications, while the D1756 has a slightly higher minimum purity specification. Please see the sample Certificate of Analysis to view the testing and specifications for each product:

      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/D1756-BULKBCCK0031.pdf
      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/D4902-BULKBCCJ0003.pdf

      役に立ちましたか？

  9. Are there any references for D2915?

    1 回答

    1. Please check the following offerings for Certified Reference standards for Dexamethasone:

      https://www.sigmaaldrich.com/product/sial/d0700000
      https://www.sigmaaldrich.com/product/sial/phr1526
      https://www.sigmaaldrich.com/product/usp/1176007

      役に立ちましたか？

  10. Can I use Product D4902 as a local application (after preparation) to induce osteogenesis in a human clinical trial?

    1 回答

    1. This product is suitable for cell culture application and is intended for research use only. For more information on "Use of Products", please consult our Terms and Conditions https://www.sigmaaldrich.com/US/en/life-science/legal/terms-and-conditions#3

      役に立ちましたか？

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