A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC50 ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.
An irreversible blocker of NF-κB and AP-1 (IC50 ≤ 15 µM) activation that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Exerts no effect on IκBα degradation of nuclear translocation p50 and p65. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in a mouse model. Reported to supress Cytochrome C release and apoptosis by activating the PI 3-K/Akt pathway.
生物化学的／生理学的作用
Cell permeable: no
Primary Target NF-κB and AP-1 activation
Product does not compete with ATP.
Reversible: no
Target IC50: ≤ 15 µM against NF-κB and AP-1 activation
包装
Packaged under inert gas
警告
Toxicity: Carcinogenic / Teratogenic (D)
再構成
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
その他情報
Xia, Y.F., et al. 2004. J. Immunol.173, 4207. Chen, J.H., et al. 2004. Biochem. Pharmacol.67, 1337. Yu, B.C., et al. 2003. Planta Med.69, 1075.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
