531413

2,2-ジフルオロ-2-(フルオロスルホニル)酢酸

97%

• 別名: (Fluorosulfonyl)difluoroacetic acid
• 化学式: FSO₂CF₂CO₂H
• CAS番号: 1717-59-5
• 分子量: 178.09
• MDL番号: MFCD01320807
• UNSPSCコード: 12352100
• PubChem Substance ID: 24877815
• NACRES: NA.22

特性

• アッセイ: 97%
• 反応適合性: reaction type: click chemistry
• 屈折率: n20/D 1.36 (lit.)
• bp: 153 °C (lit.)
• 密度: 1.723 g/mL at 25 °C (lit.)
• 官能基: carboxylic acid; fluoro
• SMILES記法: OC(=O)C(F)(F)S(F)(=O)=O
• InChI: 1S/C2HF3O4S/c3-2(4,1(6)7)10(5,8)9/h(H,6,7)
• InChI Key: VYDQUABHDFWIIX-UHFFFAOYSA-N

詳細

詳細

2,2-Difluoro-2-(fluorosulfonyl)acetic acid reagent is employed as a difluorocarbene source for difluoromethylation of phenolic hydroxyl groups.[1]

アプリケーション

2,2-Difluoro-2-(fluorosulfonyl)acetic acid may be used in the following processes:

• Preparation of 1-difluoromethyl-2-oxo-1,2-dihydropyridine analogs by reacting with the corresponding 2-chloropyridines.[2]
• Prepration of silyl fluorosulfonyldifluoroacetate as new highly efficient difluorocarbene reagent for cyclopropanation of alkenes.[3][4]
• Regio- and stereoselective free radical fluoroalkylation of terminal alkenes and alkynes with iododifluoromethanesulfonamides.[5]

安全性情報

• ピクトグラム: GHS06,GHS05
• シグナルワード: Danger
• 危険有害性情報: H300 + H310,H314
• 注意書き: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P361 + P364 - P405
• 危険有害性の分類: Acute Tox. 2 Oral - Skin Corr. 1A
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): 230.0 °F - closed cup
• 引火点(℃): 110 °C - closed cup
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges