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安全性情報

408719

Sigma-Aldrich

ポリエチレンイミン、枝状

average Mw ~800 by LS, average Mn ~600 by GPC

別名:

PEI, エチレンジアミン 枝状

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100 ML
￥12,800
250 ML
￥24,500
1 L
￥61,000

￥12,800

出荷可能日2025年4月21日詳細

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100 ML
￥12,800
250 ML
￥24,500
1 L
￥61,000

About This Item

化学式:
H(NHCH2CH2)nNH2
CAS番号:
25987-06-8
MDL番号:
MFCD00084427
UNSPSCコード:
12162002
NACRES:
NA.23

￥12,800

出荷可能日2025年4月21日詳細

バルクの問い合わせ

フォーム

viscous liquid

品質水準

200

分子量

average Mn ~600 by GPC
average Mw ~800 by LS

屈折率

n20/D 1.5240

密度

1.050 g/mL at 25 °C

SMILES記法

N1CC1.NCCN

InChI

1S/C2H8N2.C2H5N/c3-1-2-4;1-2-3-1/h1-4H2;3H,1-2H2

InChI Key

SFLOAOINZSFFAE-UHFFFAOYSA-N

関連するカテゴリー

詳細

ポリエチレンイミンは親水性ポリマーで、治療用核酸のin vivo送達のための非ウイルス性合成ベクターとして広く使用されています。その優れた物理化学的特性のため、タンパク質の分離・精製、二酸化炭素吸収、薬物担体、流出液処理、生体標識などの多数の分野で使用されています。

アプリケーション

分岐状PEIは、効率的な遺伝子導入のための複合ポリプレックスを合成するための前駆体として使用できます。PEIのJeffamineポリエーテルとの結合およびPEIのアミノ基のグアニジニル化により、ポリプレックスの細胞毒性が低減し、血清タンパク質の存在下で凝集から保護されます。

PEIに浸漬した竹炭は、CO2 吸着剤として使用できます。PEIに存在する多数のアミノ基は、酸アルカリ相互作用によりCO2 と反応して、竹炭の吸着能を高めることができます。

また、有機薬物分子に対する高い配位能力を持つ架橋水溶性ポリマーの調製にも使用できます。

特徴および利点

  • 分岐状PEIは、複合体形成能や 干渉能が向上しています。
  • 高いイオン交換能と タンパク質に対する高い親和性。
  • 非常に高いDNA移入効率。

物理的形状

分岐ポリマ-

ピクトグラム

CorrosionExclamation markEnvironment
GHS05,GHS07,GHS09

シグナルワード

Danger

危険有害性情報

H302,H318,H411

危険有害性の分類

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1

保管分類コード

10 - Combustible liquids

WGK

WGK 3

引火点(°F)

356.0 °F

引火点(℃)

180 °C

個人用保護具 (PPE)

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

消防法

第4類:引火性液体
第三石油類
危険等級III
非水溶性液体

Jan Code

408719-100ML:
408719-BULK:
408719-VAR:
408719-250ML:
408719-1L:

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number
WXBF4895V
MKCV6718
MKCJ2767
MKCG7251
MKCG3800

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Slide 1 of 5

1 of 5

ポリ（エチレンイミン） 溶液 ~50% in H2O

Sigma-Aldrich

03880

ポリ（エチレンイミン） 溶液

ポリ（エチレンイミン） 溶液 analytical standard, 50 % (w/v) in H2O

Supelco

P3143

ポリ（エチレンイミン） 溶液

Polyethylenimine 塩酸塩 linear, average Mn 10,000, PDI ≤1.5

Sigma-Aldrich

764647

Polyethylenimine 塩酸塩

Polyethylenimine 塩酸塩 linear, average Mn 4,000, PDI ≤1.3

Sigma-Aldrich

764892

Polyethylenimine 塩酸塩

Polyethylenimine on silica gel powder, 40-200 mesh

Sigma-Aldrich

246751

Polyethylenimine on silica gel

Valentina Dinca et al.
Sensors (Basel, Switzerland), 18(12) (2018-12-07)
Developing a controlled method for obtaining hybrid enzymatic-based interfaces for sensing application require the use of a multiuse, reusable sensor. By controlling the interface characteristics in terms of the surface chemistry, thickness, and roughness, a tailored response toward various toxic
Andrew Jajack et al.
PloS one, 14(1), e0210286-e0210286 (2019-01-17)
Insurmountable detection challenges will impede the development of many of the next-generation of lab-on-a-chip devices (e.g., point-of-care and real-time health monitors). Here we present the first membrane-based, microfluidic sample preconcentration method that is continuous, quantifiable, simple, and capable of working
Irena Mamajanov et al.
Life (Basel, Switzerland), 10(8) (2020-08-23)
Enzymes are biological catalysts that are comprised of small-molecule, metal, or cluster catalysts augmented by biopolymeric scaffolds. It is conceivable that early in chemical evolution, ancestral enzymes opted for simpler, easier to assemble scaffolds. Herein, we describe such possible protoenzymes:
Jonathon M Muncie et al.
Developmental cell, 55(6), 679-694 (2020-11-19)
Embryogenesis is directed by morphogens that induce differentiation within a defined tissue geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) adhesions and is modulated by cell tension and tissue-level forces. Whether cell tension regulates development by modifying
Anna Alhaddad et al.
PloS one, 7(12), e52207-e52207 (2013-01-04)
Small interfering RNAs (siRNAs) are powerful tools commonly used for the specific inhibition of gene expression. However, vectorization is required to facilitate cell penetration and to prevent siRNA degradation by nucleases. We have shown that diamond nanocrystals coated with cationic
関連する文献をすべて表示

資料

Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting

Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.

Functionalized PEI and Its Role in Gene Therapy

Gene therapy has become one of the most discussed techniques in biomedical research in recent years.

腫瘍標的化のためのナノ粒子薬物および遺伝子送達

Professor Katayamaは、EPR効果を利用した薬物送達システムについて、新素材による刺激応答性システムに焦点を当てて説明しています。

Progress on Nonviral Delivery for CRISPR/Cas9

CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.

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質問

1–9/9 質問  

  1. This product is cells transfection grade, right? compared to Polyethylenimine, branched 408727?

    1 回答

    1. This product is classified as reagent grade, not cell transfection grade. Similarly, product 408727 (Polyethylenimine, branched) is also categorized as reagent grade. Therefore, neither product is specifically tested for cell transfection purposes.

      役に立ちましたか？

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 回答

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      役に立ちましたか？

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 回答

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      役に立ちましたか？

  4. 1) What is the maximum wt % absorption of CO2 relative to the weight of PEI 2) Does PEI liquid absorb CO2 by surface absorption/adhesion - or by diffusion into the fluid?

    1 回答

    1. Theoretically, it’s about equal amounts of CO2 and PEI by mass. The effective monomeric unit of the PEI is the (-CH2CH2NH-) group, with a formula weight of 43.07. The formula weight of carbon dioxide is 44.01. Each monomeric unit of the PEI can react with one molecule of CO2, and since 43.07 is so close to 44.01, the weight of the PEI and the CO2 would be almost the same. Practically speaking, the reaction is probably not 100% efficient.
      The PEI absorbs the CO2 by a chemical reaction…an acid-base reaction. Carbon dioxide in aqueous solution is sometimes referred to as carbonic acid. (CO2 + H2O ---> H2CO3) And the amino groups of the PEI are the base. The reaction product is a protonated amine (-NH3 + or -NHR2 +) with a bicarbonate anion (HCO3 - ) as the counterion.

      役に立ちましたか？

  5. What is the vapor pressure for Polyethylenimine 800 at room temperature?

    1 回答

    1. Please download the current Safety Data Sheet (SDS) for this product from sigmaaldrich.com for your geography and language. Neither a vapor pressure nor an evaporation rate is reported in Section 9 of the SDS for this low molecular weight polyamine. However, since respiratory protection is recommended in Section 8 of the SDS, one could infer that this product is volatile enough to have a measurable vapor pressure.

      役に立ちましたか？

  6. Is this product soluble in water ?

    1 回答

    1. This material is readily soluble in water, ethanol, methanol, isopropanol, and n-propanol. In addition, the product is partially soluble in ethyl acetate, toluene, and xylene. Other sources report that this PEI is also soluble in chloroform.

      役に立ちましたか？

  7. What is the percentage of Polyethylenimine in the solution?

    1 回答

    1. This product is considered a neat/pure material. It just happens to be a liquid at room temperature, but it is not in solution; there is no solvent added.

      役に立ちましたか？

  8. What is the n value in the structure of this PEI?

    1 回答

    1. The n value in the structure is not determined.

      役に立ちましたか？

  9. What's the molar ratio of primary, secondary and tertiary amines?

    1 回答

    1. The molar ratio of the primary, secondary, and tertiary amines is not determined. However, the amine value is approximately 576 (primary and secondary). This product is PEI800 and equivalent to Lupasol FG.
      See the link below for a paper that suggests a general amine ratio (Table 6):
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872989/

      役に立ちましたか？

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