317519

2-アセトアミドアクリル酸メチル

98%

• 化学式: H₂C=C(NHCOCH₃)CO₂CH₃
• CAS番号: 35356-70-8
• 分子量: 143.14
• MDL番号: MFCD00013394
• UNSPSCコード: 12162002
• PubChem Substance ID: 24859082
• NACRES: NA.23

特性

• 品質水準: 100
• アッセイ: 98%
• bp: 104 °C/8 mmHg (lit.)
• mp: 50-52 °C (lit.)
• SMILES記法: COC(=O)C(=C)NC(C)=O
• InChI: 1S/C6H9NO3/c1-4(6(9)10-3)7-5(2)8/h1H2,2-3H3,(H,7,8)
• InChI Key: SMWNFFKPVLVOQQ-UHFFFAOYSA-N

詳細

詳細

Conjugated addition of secondary amines, imidazole and pyrazole to methyl 2 methyl 2-acetamidoacrylate in the presence of a catalyst results in the formation of β-Dialkylamino-α-alanine and β-(N-heteroaryl)-α-alanine derivatives.[1] Methyl-2-acetamidoacrylate (M2AA) is an anti-inflammatory agent. [2] The catalytic reaction of methyl 2-acetamidoacrylate with Grignard′s reagents affords α-amino esters. [3] M2AA can form thermosensitive copolymers with methyl acrylate. [4]

Methyl ester of 2-acetamidoacrylate . [5] methyl 2-acetamidoacrylate (Me-2-AA) is a di-unsaturated α-amino acid derivative.[6] methyl-2-acetamidoacrylate exihibits anti -inflammatory properties, it is very effective against lipopolysaccharide (LPS)- induced nitric oxide production by RAW 264. [7][5]

アプリケーション

Methyl 2-acetamidoacrylate can undergo [2+2] cycloaddition (Michael–Dieckmann-type reaction) with ketene diethyl acetal to yield the cyclobutane core. [8] It may be used in rhodium-catalyzed 2-alkenylpyrrole formation.[9]

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): 235.4 °F - closed cup
• 引火点(℃): 113 °C - closed cup
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves