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U6628

Sigma-Aldrich

Uvaol

≥95%

Sinonimo/i:

Urs-12-ene-3,28-diol

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About This Item

Formula empirica (notazione di Hill):
C30H50O2
Numero CAS:
545-46-0
Peso molecolare:
442.72
Numero CE:
208-888-3
Numero MDL:
MFCD00009620
Codice UNSPSC:
12352103
ID PubChem:
24900437
NACRES:
NA.25

Saggio

≥95%

Punto di fusione

223-225 °C (lit.)

applicazioni

metabolomics
vitamins, nutraceuticals, and natural products

Stringa SMILE

C[C@@H]1CC[C@]2(CO)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C

InChI

1S/C30H50O2/c1-19-10-15-30(18-31)17-16-28(6)21(25(30)20(19)2)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h8,19-20,22-25,31-32H,9-18H2,1-7H3/t19-,20+,22+,23-,24+,25+,27+,28-,29-,30-/m1/s1
XUARCIYIVXVTAE-ZAPOICBTSA-N

Informazioni sul gene

mouse ... Nos2(18126)

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Categorie correlate

Descrizione generale

Uvaolis a pentacyclic triterpene compound usually extracted from plant leaves such as Apocynum venetum L., olive leaves (Olea europaea L.), and oregano (Origanum vulgare L.).

Applicazioni

Uvaol has been used as retinoic acid receptor-related orphan receptor gamma t (RORγt) inhibitor to study the role of cardiac glycoside reductase 2 (Cgr2) enzyme on its metabolism.

Azioni biochim/fisiol

Uvaolexerts pharmacological properties such as antioxidant, anticancer, anti-inflammatory, and wound healing. It also displays vasodilator, hepatoprotective, and antimicrobial effects. Uvaol has inhibitory effects on nitric oxide (NO) release.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Fucosterol ≥93%

Sigma-Aldrich

F5379

Fucosterol

Soyasapogenol B ≥98% (HPLC)

Sigma-Aldrich

SMB00460

Soyasapogenol B

Δ 5-avenasterol Avanti Research™ - A Croda Brand

Avanti

700174P

Δ 5-avenasterol

Brassicasterol Avanti Research™ - A Croda Brand

Avanti

700175P

Brassicasterol

Lanosterol ≥93%, powder

Sigma-Aldrich

L5768

Lanosterol

Oleanolic acid ≥97%

Sigma-Aldrich

O5504

Oleanolic acid

α-Amyrin analytical standard

Supelco

53017

α-Amyrin

Lupeol analytical standard

Supelco

18692

Lupeol

Betulin analytical standard

Supelco

92648

Betulin

X Z Xu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 25(4), 225-226 (2003-01-07)
To study the chemical components of Gentiana tizuensis distributed in Qinghai Province. Chromatography and spectral analyses were used to isolate the constituents and elucidate their structure. Four compounds were isolated and identified as uvaol, L-(+)-l-O-methyl-myo-inositol, ursolic acid,beta-sitosterol. All these components
L I Somova et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 11(2-3), 121-129 (2004-04-09)
The cardiotonic and antidysrhythmic effects of four triterpenoid derivatives, namely oleanolic acid (OA), ursolic acid (UA), and uvaol (UV), isolated from the leaves of African wild olive (Olea europaea, subsp. africana) as well as methyl maslinate (MM) isolated from the
De-Hong Huang et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 34(3), 375-378 (2011-08-10)
To study the chemical constituents of Coleus forskohlii. Isolation and purification were carried out by silica gel column chromatographic and Toyopearl HW-40F. Compounds were identified and elucidated by spectral and chemical methods. Seven compounds were obtained from ethyl acetate extract
A Martins et al.
Anticancer research, 30(3), 829-835 (2010-04-16)
A bioassay-guided separation protocol, including the testing of the extracts, fractions and pure compounds for their ability to inhibit P-glycoprotein (the efflux pump responsible for the multidrug resistance of the used cell line) of mouse lymphoma cells containing the human
Margaret Alexander et al.
Cell host & microbe, 30(1), 17-30 (2021-11-26)
Bacterial activation of T helper 17 (Th17) cells exacerbates mouse models of autoimmunity, but how human-associated bacteria impact Th17-driven disease remains elusive. We show that human gut Actinobacterium Eggerthella lenta induces intestinal Th17 activation by lifting inhibition of the Th17
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