T7947
(R)-Tomoxetine hydrochloride
solid
Sinonimo/i:
(R)-N-Methyl-γ-(2-methylphenoxy)benzenepropanamine hydrochloride, Atomoxetine hydrochloride
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Scegli un formato
25 MG
548,00 €
100 MG
1.480,00 €
Scegli un formato
Cambia visualizzazione
25 MG
548,00 €
100 MG
1.480,00 €
About This Item
Formula empirica (notazione di Hill):
C17H21NO · HCl
Numero CAS:
Peso molecolare:
291.82
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Stato
solid
Ideatore
Eli Lilly
Temperatura di conservazione
2-8°C
Stringa SMILE
CNCC[C@@H](OC1=CC=CC=C1C)C2=CC=CC=C2.[H]Cl
InChI
1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
LUCXVPAZUDVVBT-UNTBIKODSA-N
Informazioni sul gene
human ... SLC6A2(6530)
Cerchi prodotti simili? Visita Guida al confronto tra prodotti
Applicazioni
(R)-Tomoxetine hydrochloride has been used as a noradrenaline reuptake inhibitor:
- to study the role of L-threo-3,4-dihydroxyphenylserine (L-DOPS) in the pathogenesis of Alzheimer′s disease in mice[1]
- to study its effects on set shifting in rats[2]
- to study its effects on rat brain as a result of its long-term use[3]
Azioni biochim/fisiol
(R)-Tomoxetine hydrochloride is an efficient inhibitor of presynaptic norepinephrine transporters.[4] It also positively regulates the release of acetylcholine in the prefrontal cortex (PFC).[2] (R)-Tomoxetine hydrochloride binds to the serotonin (5-HT) transporter.[2] It is involved in blocking the cortical N-methyl-D-aspartate (NMDA) receptors.[2]. (R)-Tomoxetine hydrochloride exhibits therapeutic effects against attention-deficit/hyperactivity disorder (ADHD) and comorbid oppositional defiant disorder (ODD).[4]
Norepinephrine uptake blocker.
Caratteristiche e vantaggi
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Scegli una delle versioni più recenti:
Certificati d'analisi (COA)
Lot/Batch Number
Non trovi la versione di tuo interesse?
Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Fatma Gür et al.
Biochemical and biophysical research communications, 534, 927-932 (2020-11-05)
Attention Deficit Hyperactivity Disorder (ADHD) is the most common psychiatric disorder reported particularly in children. Long-term use of antipsychotic drugs used in the treatment of ADHD has been shown to exert toxic effects on the brain. However, not enough research
Grazia Dell'Agnello et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 19(11), 822-834 (2009-09-01)
The primary aim of this study was to assess the efficacy of atomoxetine in improving ADHD and ODD symptoms in paediatric patients with ADHD and comorbid oppositional defiant disorder (ODD), non-responders to previous psychological intervention with parent support. This was
Romano Arcieri et al.
Journal of child and adolescent psychopharmacology, 22(6), 423-431 (2013-01-31)
The purpose of this study was to assess the cardiovascular effects of drugs used for attention-deficit/hyperactivity disorder (ADHD) in children and adolescents treated in community care centers in Italy. This study was an open, prospective, observational study of youth with
Christina A Wilson et al.
Pharmacology, biochemistry, and behavior, 104, 47-61 (2013-01-05)
Rats repeatedly exposed to variable prenatal stress (PNS) exhibit behavioral signs that are similar to those manifested in several neuropsychiatric disorders such as deficits in attention and inhibitory control, and impairments in memory-related task performance. The purpose of the study
Himanshu P Upadhyaya et al.
Psychopharmacology, 226(2), 189-200 (2013-02-12)
Treatment of attention-deficit/hyperactivity disorder (ADHD) has for many years relied on psychostimulants, particularly various formulations of amphetamines and methylphenidate. These are central nervous system stimulants and are scheduled because of their abuse potential. Atomoxetine (atomoxetine hydrochloride; Strattera®) was approved in
Filtri attivi
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.
