SML1809

PPTN trifluoroacetate salt

≥98% (HPLC)

• Sinonimo/i: 4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid trifluoroacetate salt
• Formula empirica (notazione di Hill): C₂₉H₂₄F₃NO₂ · C₂HF₃O₂
• Numero CAS: 1160271-30-6
• Peso molecolare: 589.52
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 10 mg/mL, clear
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: OC(C1=CC2=CC(C3=CC=C(C(F)(F)F)C=C3)=CC=C2C(C4=CC=C(C5CCNCC5)C=C4)=C1)=O.FC(F)(C(O)=O)F
• InChI: 1S/C29H24F3NO2.C2HF3O2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20;3-2(4,5)1(6)7/h1-10,15-17,20,33H,11-14H2,(H,34,35);(H,6,7); UAHMBIXBIRLMAG-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

PPTN is a P2Y14 receptor antagonist.

PPTN is a very potent (IC₅₀ = 1 nM) P2Y14 receptor antagonist that does not interact with any other P2Y receptor at concentrations up to 10 μM. PPTN blocks UDP-glucose inhibition of forskolin-induced cAMP accumulation, and neutrophil chemotaxis towards UDP-glucose gradients with nM potency.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable