M5571

Miltefosine

≥98% (perchloric acid titration)

• Sinonimo/i: Choline hexadecyl phosphate, HePC, Hexadecyl phosphocholine
• Formula empirica (notazione di Hill): C₂₁H₄₆NO₄P
• Numero CAS: 58066-85-6
• Peso molecolare: 407.57
• Numero MDL: MFCD00133396
• Codice UNSPSC: 51191904
• ID PubChem: 329818017
• NACRES: NA.85

Proprietà

• Origine biologica: synthetic (organic)
• Descrizione: zwitterionic
• Saggio: ≥98% (perchloric acid titration)
• Stato: powder
• Solubilità: H₂O: 10 mg/mL, clear, colorless
• Gruppo funzionale: phospholipid
• Tipo di lipide: phospholipids
• Temperatura di conservazione: room temp
• Stringa SMILE: [O-]P(OCC[N+](C)(C)C)(OCCCCCCCCCCCCCCCC)=O
• InChI: 1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3; PQLXHQMOHUQAKB-UHFFFAOYSA-N

Descrizione

Applicazioni

• Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents.: This study underlines the necessity for innovative treatments amidst growing resistance to established drugs such as miltefosine which is used as a positive control reference, potentially setting a new direction for antileishmanial drug development (Ciccone et al., 2024).

Azioni biochim/fisiol

Inhibitor of protein kinase C and of phosphatidylcholine synthesis. Used for the treatment of visceral and cutaneous leishmaniasis. Active against metronidazole-resistant and -susceptible strains of Trichomonas vaginalis

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301
• Consigli di prudenza: P264 - P270 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 3 Oral
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves