SML1527

Abiraterone acetate

≥98% (HPLC)

• Sinonimo/i: CB 7598, 17-(Pyridin-3-yl)androsta-5,16-dien-3β-yl acetate
• Formula empirica (notazione di Hill): C₂₆H₃₃NO₂
• Numero CAS: 154229-18-2
• Peso molecolare: 391.55
• Numero MDL: MFCD00934213
• Codice UNSPSC: 12352200
• ID PubChem: 329825944
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 5 mg/mL, clear
• Temperatura di conservazione: −20°C
• Stringa SMILE: C[C@]12C(C[C@@H](OC(C)=O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=CC=CN=C5
• InChI: 1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1; UVIQSJCZCSLXRZ-UBUQANBQSA-N
• Informazioni sul gene: human ... CYP17A1(1586)

Descrizione

Applicazioni

Abiraterone acetate has been used to study its antitumor action in 3D micro-tumour platform.[1]

Azioni biochim/fisiol

Abiraterone acetate is a prodrug of abiraterone, which is a potent, selective, and orally bioavailable inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17α hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Abiraterone acetate is used for the treatment of metastatic castration-resistant prostate cancer.[2][3] Abiraterone acetate possesses significant antitumor activity in post-docetaxel patients with CRPC (castration-resistant prostate cancer). It is highly essential for androgen biosynthesis in the testes, adrenal glands, and prostate tissue.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H360F,H373,H410
• Consigli di prudenza: P202 - P260 - P273 - P280 - P308 + P313 - P391
• Classi di pericolo: Aquatic Chronic 1 - Repr. 1B - STOT RE 2
• Organi bersaglio: Endocrine system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable